Synthetic peptides derivatives with nerve growth factor-like neu

Details Synthetic peptides derivatives with nerve growth factor-like neu Synthetic peptides derivatives with nerve growth factor-like neu

1996-03-29

1999-09-28

Tsang, Cecilia J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 13, 514 14, 514 15, 514 16, 514 17, 530326, 530327, 530328, 530329, 530330, A61K 3812, C07K 512

Patent

active

059588756

ABSTRACT:
This invention provides compounds displaying NGF agonist activity, wherein the compounds comprise a multimer of a sequence of amino acid residues or biologically functional equivalents thereof, the sequence being substantially homologous to residues 29-38 of NGF, residues 43-47 of NGF or residues 92-97 of NGF. Preferably, the multimer is a cyclic dimer wherein the monomeric amino acid sequences are linked to each other by disulfide bridges. This invention also provides methods and compositions for the treatment of disorders involving NGF-responsive cells, by administering an effective amount of the multimeric NGF agonists of this invention to an individual suffering from such disorder.

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