Synthetic peptides, conjugation reagents and methods

Details Synthetic peptides, conjugation reagents and methods Synthetic peptides, conjugation reagents and methods

2007-03-20

2007-03-20

Kam, Chih-Min (Department: 1656)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

C530S305000, C530S326000, C530S327000, C514S002600, C514S012200, C514S023000, C514S025000, C514S052000, C435S325000, C536S018600, C560S019000

Reexamination Certificate

active

11221199

ABSTRACT:
The invention provides methods and compositions useful for making synthetic peptide conjugates. In one embodiment, the invention provides compositions comprising the structure:wherein R is selected from lower substituted or unsubstituted alkyl, O, NH and S and P is an amine protection group. In more particular embodiments, the compositions comprise α-amine protected 4,5-dehydroleucine or α-amine protected (2S)-aminolevulinic acid and/or P is F-moc. These compounds may be incorporated into peptides, for example, peptides comprising a substituted or unsubstituted (2S)-aminolevulinic acid residue, such as (2S)-aminolevulinic acid residue is substituted with an O- or N-linked glycoconjugate, or a detectable label.

REFERENCES:
patent: 6465612 (2002-10-01), Bertozzi et al.
patent: 6939945 (2005-09-01), Bertozzi et al.

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