Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Reexamination Certificate
2001-05-25
2010-10-26
Lucas, Zachariah (Department: 1648)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
C424S184100, C435S069100, C435S005000
Reexamination Certificate
active
07820786
ABSTRACT:
Aspects of the present invention are related to a synthetic polypeptide comprising a plurality of different segments from one or more parent polypeptides, linked together in such a way that is different from their linkage in the one or more parent polypeptides, in such way as to impede, abrogate or otherwise alter at least one function associated with the linkage in the one or more parent polypeptides, and in such a way that their product is not similar in function and/or structure to at least a portion of the one or more parent polypeptides. Additional aspects include a synthetic polynucleotide encoding the synthetic polypeptide, methods of production, a synthetic construct and methods of using the synthetic polypeptide, nucleotide construct and compositions comprising the above. Another aspect is directed towards a computer program product for designing these synthetic polypeptides and polynucleotides.
REFERENCES:
patent: 5639854 (1997-06-01), Sia et al.
patent: WO 93/08280 (1993-04-01), None
patent: WO 99/41368 (1999-08-01), None
patent: WO 99/41369 (1999-08-01), None
patent: WO99/41369 (1999-08-01), None
patent: WO 99/41402 (1999-08-01), None
patent: WO 00/18906 (2000-04-01), None
Wilkinson, B.M. “Distinct Domains within Yeast Sec61p Involved in Post-translational Translocations and Protein Dislocation” J. Biol. Chem. 2000; 275, 1:521-529.
Arthos et al. Simian Immunodeficiency Virus DNA Vaccine Trial in Macaques. 1996, Journal of Virology, vol. 70, p. 3978-3991.
Vaccine Concepts/Design, The NIAID Division of AIDS, 2003, p. 1-6.
Lieberman et al. Blood, 1997, vol. 90, p. 2196-2206.
Ada, G. L. (1993) Vaccines. Fundamental Immunology, Third Edition, William E. Paul, Raven Press, Ltd., New York. pp. 1309-1352.
An, L. L. and Whitton, J. L. (1997) A Multivalent Minigene Vaccine, Containing B-Cell, Cytotoxic T-Lymphocyte, and ThEpitopes from Several Microbes, Induces Appropriate Responses In Vivo and Confers Protection against More than One Pathogen. J. Virol. 71(3):2292-2302.
Boyle, D. B., et al. (1985) Multiple-cloning-site plasmids for the rapid construction of recombinant poxviruses. Gene 35:169-177.
Brown, J. H., et al. (1993) Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1. Nature 364:33-39.
Chicz, R. M., et al. (1993) Specificity and Promiscuity among Naturally Processed Peptides Bound to HLA-DR Alleles. J. Exp. Med. 178:27-47.
Coward, E. (1999) Shufflet: shuffling sequences while conserving the κ-let counts. Bioinformatics 15(12):1058-1059.
Crameri, A., et al. (1998) DNA shuffling of a family of genes from diverse species accelerates directed evolution. Nature 391:288-291.
Del Val, M., et al. (1991) Efficient Processing of an Antigenic Sequence for Presentation by MHC Class I Molecules Depends on Its Neighboring Residues in the Protein. Cell 66:1145-1153.
Dyall, R., et al. (1995) CD4-independent in vivo priming of murine CTI by optimal MHC class I-restricted peptides derived from intracellular pathogens. Int. Immunol. 7(8)1205-1212.
Fisch, I., et al. (1996) A strategy of exon shuffling for making large peptide repertoires displayed on filamentous bacteriophage. PNAS 93:7761-7766.
Fremont, D. H., et al. (1992) Crystal Structures of Two Viral Peptides in Complex with Murine MHC Class I H-2Kb. Science 257:919-927.
Gao, F., et al. (1996) The Heterosexual Immunodeficiency Virus Type 1 Epidemic in Thailand Is Caused by an Intersubtype (A/E) Recombinant of African Origin. J. Virol. 70(10):7013-7029.
Giver, L. and Arnold, F. (1998) Combinatorial protein design by in vitro recombination: Current Opinion in Chem. Biol. 2:335-338.
Goulder, P. J. R., et al. (1997) Patterns of Immunodominance in HIV-1-specific Cytotoxic T Lymphocyte Responses in Two Human Histocompatibility Leukocyte Antigens (HLA)-identical Siblings with HLA-A*0201 Are Influenced by Epitope Mutation. J. Exp. Med. 185(8):1423-1433.
Ishioka, G. Y., et al. (1999) Utilization of MHC Class I Transgenic Mice for Development of Minigene DNA Vaccines Encoding Multiple HLA-Restricted CTL Epitopes. J. Immunol. 162:3915-3925.
Kent, S. J., et al. (1998) Enhanced T-Cell Immunogenicity and Protective Efficacy of a Human Immunodeficiency Virus Type 1 Vaccine Regimen Consisting of Consecutive Priming with DNA and Boosting with Recombinant Fowlpox Virus. J. Virol. 72(12):10180-10188.
Kwong, P. D., et al. (1998) Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody. Nature 393:648-659.
Mizuuchi, K., et al. (1982) T4 Endonuclease VII Cleaves Holliday Structures. Cell 29:357-365.
Newcomb, J. R. and Cresswell, P. (1993) Characterization of Endogenous Peptides Bound to Purified HLA-DR Molecules and Their Absence from Invariant Chain-Associated αβ Dimers. J. Immunol. 150:499-507.
Ogg, G. S., et al. (1998) Quantitation of HIV-1-Specific Cytotoxic T Lymphocytes and Plasma Load of Viral RNA. Science 279:2103-2106.
Parmiani, G. (1998) Future Perspectives in Specific Immunotherapy of Melanoma. Eur. J. Cancer 34(Suppl 2):S42-S47.
Patten, P. A., et al. (1997) Applications of DNA shuffling to pharmaceuticals and vaccines. Curr. Opin. Biotechnol. Pharmaceutical Biotech. 8(6):724-733.
Persson, H., et al. (1980) Multiple mRNA species for the precursor to an adenovirus-encoded glycoprotein: Identification and structure of the signal sequence. PNAS 77(11):6349-6353.
Punnonen, J. (2000) Molecular Breeding of Allergy Vaccines and Antiallergic Cytokines. Int. Arch. Allergy Immunol. 121:173-182.
Rotzschke, O., et al. (1990) Isolation and analysis of naturally processed viral peptides as recognized by cytotoxic T cells. Nature 348:252-254.
Rowland-Jones, S., et al. (1995) HIV-specific cytotoxic T-cells in HIV-exposed but uninfected Gambian women. Nature Medicine 1(1):59-64.
Rowland-Jones, S., et al. (1998) Cytotoxic T Cell Responses to Multiple Conserved HIV Epitopes in HIV-Resistant Prostitutes in Nairobi. J. Clin. Invest. 102(9)1758-1765.
Ryu, D. D. Y. and Nam, D. H. (2000) Recent Progress in Biomolecular Engineering. Biotechnol. Prog. 16:2-16.
Salminen, M. O., et al. (1996) Full-Length Sequence of an Ethiopian Human Immunodeficiency Virus Type 1 (HIV-1) Isolate of Genetic Subtype C. Aids Res. Human Retroviruses 12(14):1329-1339.
Sandhu, G. S., et al. (1992) Dual Asymmetric PCR: One-Step Construction of Synthetic Genes. BioTechniques 12(1):14-16.
Stemmer, W. P. C. (1994) DNA shuffling by random fragmentation and reassembly: In vitro recombination for molecular evolution. PNAS 91:10747-10751.
Stemmer, W. P. C. (1994) Rapid evolution of a protein in vitro by DNA shuffling. Nature 370:389-391.
Thomson, S. A., et al. (1995) Minimal epitopes expressed in a recombinant polyepitope protein are processed and presented to CD84+cytotoxic T cells: Implications for vaccine design. PNAS 92:5845-5849.
Thomson, S. A., et al. (1996) Recombinant Polyepitope Vaccines for the Delivery of Multiple CD8 Cytotoxic T Cell Epitopes. J. Immunol. 157:822-826.
Thomson, S. A., et al. (1998) Delivery of Multiple CD8 Cytotoxic T Cell Epitopes by DNA Vaccination. J. Immunol. 160:1717-1723.
Thomson, S. A., et al. (1998) Targeting a Polyepitope Protein Incorporating Multiple Class II-Restricted Viral Epitopes to the Secretory/Endocytic Pathway Facilitates Immune Recognition by CD4+cytotoxic T Lymphocytes: a Novel Approach to Vaccine Design. J. Virol. 72(3):2246-2252.
Townsend, A. R. M., et al. (1986) The Epitopes of Influenza Nucleoprotein Recognized by Cytotoxic T Lymphocytes Can Be Defined with Short Synthetic Peptides. Cell 44:959-968.
Woodberry, T., et al. (1999) Immunogenicity of a Human Immunodeficiency Virus (HIV) Polytope Vaccine Containing Multiple HLA A2 HIV CD8+Cytotoxic T-Cell Epitopes. J. Virol. 73(7):5320-5325.
Youil, R., et al. (1995) Screening for mutations by enzyme mismatch cleavage with T4 endonuclease VII. PNAS 92:87-91.
Zhao, H., et al. (1998) Molecular evolution by staggered extension process (StEP) in vitro recombination. Nature Biotechnol. 16:258-261.
Lieberman, J. et al. 1992 “Cytotoxic T Lymphocytes from HIV-1 seropositive indiv
Ramshaw Ian Alistair
Thomson Scott Anthony
Boesen Agnieszka
Knobbe Martens Olson & Bear LLP
Lucas Zachariah
Savine Therapeutics Pty Ltd
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