Synthetic peptides and use thereof in preparing calmodulin antis

Details Synthetic peptides and use thereof in preparing calmodulin antis Synthetic peptides and use thereof in preparing calmodulin antis

1985-08-26

1987-12-29

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 15, 514 16, 530326, 530327, 530328, H61K 3702, C07K 708, C07K 706

Patent

active

047161507

ABSTRACT:
The compounds of the present invention are synthetic peptides useful in developing antisera against vertebrate or plant calmodulins. The peptides have chain lengths of from 8 to 15 amino acids arranged in linear N-terminal to C-terminal sequences which include either the amino acid segment asparagine-tyrosine-glutamic acid-glutamic acid-phenylalanine-valine-glutamine, corresponding to a minimal immunoreactive site of vertebrate calmodulin, or the segment asparagine-tyrosine-glutamic acid-glutamic acid-phenylalanine-valine-lysine, corresponding to the analogous amino acid regin of plant calmodulin.

REFERENCES:
Watterson et al., (1976) J. Biol. Chem. 251 (15) 4501-4513.
Van Eldik, et al., (1981) J. Biol. Chem. 256 (9) 4205-4210.
Proceedings of the Nat'l. Acad. Sci. 80 (22) 1983 pp. 6775-6779.
European Journal of Biochem. 113, No. 2 (1981) 359-367.

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