Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 8 to 10 amino acid residues in defined sequence
Reexamination Certificate
2006-05-30
2006-05-30
Lukton, David (Department: 1654)
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
8 to 10 amino acid residues in defined sequence
C530S329000, C530S345000, C514S015800, C514S016700, C514S017400
Reexamination Certificate
active
07053178
ABSTRACT:
Synthetic peptides and derivatives thereof capable of inhibiting the biological activity of anti-beta-2-glycoprotein 1 (β2GPI) monoclonal antibodies (mAbs) in vitro, and of inhibiting induction of experimental anti-phospholipid syndrome (APS) in mice by anti-β2GPI mAbs, are provided for the diagnosis and treatment of anti-phospholipid syndrome in humans.
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Wang M X et al: “Epitope specificity of monoclonal anti-beta 2-glycoprotein l antibodies derived from patients wiht the antiphospholipid syndrome.”, Journal of Immkunology, (Aug. 1, 1995) 155 (3) 1629-36., XP002125557.
George E.A.: “Differential effects of anti-beta-2-glycoprotein l antibodies on endothelial cells and on the manifestations of experimental antiphospholipid syndrome”, Circulation vol. 97, No. 9, Mar. 10, 1998, p. 900-906.
Blank E.A.: “Prevention of experimental antiphospholipid syndrome and endothelial cell activation by synthetic peptides”, Proceedings of the National Academy of Sciences Of USA, vol. 96, Apr. 1999, pp. 5164-5168, XP00212556.
Blank Miri
Cabilly Shmuel
Katchalski-Katzir Ephraim
Shoenfeld Yehuda
Browdy and Neimark PLLC
Lukton David
Yeda Research Development Co., LTD
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