Synthetic peptides

Details Synthetic peptides Synthetic peptides

1993-09-07

1996-05-14

Woodward, Michael P.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

4241881, 530324, 530325, 530326, 530327, 530328, 530329, 514 12, 514 13, 514 14, 514 15, 514 16, 514 17, C12Q 170, C07K 708, A61K 3810, A61K 3921

Patent

active

055166326

ABSTRACT:
The present invention relates to immunogenic preparations of peptides comprising amino acid sequences corresponding to antigenic determinants of the envelope glycoprotein of HTLV-I or HTLV-II covalently coupled, directly or through a spacer molecule, to carrier molecules suitable for vaccination of mammals. The invention also relates to the use of such peptides in diagnostic assays.

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Palker et al, "Mapping of Homologous, Amino-Terminal Neutralizing Regions of Human T-Cell Lymphotropic Virus Type I and II gp46 Envelope Glycoproteins", Journal of Virology 66(10):5879-5889 (1992).
Ralston et al, "Identification and Synthesis of the Epitope for a Human Monoclonal Antibody Which Can Neutralize Human T-cell Leukemia/Lymphotrophic Virus TypeI*", The Journal of Biological Chemistry, vol. 284, No. 28, pp. 16343-16346 (1989).
Lipka et al, "Determination of a Unique and Immunodominant Epitope of Human T Cell Lymphotrophic Virus Type I", The Journal of Infectious Diseses, 162:353-357 (1990).
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Tanaka J. of Immunol. 147:354 (1991).
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