Synthetic peptide lung surfactants having covalently bonded anti

Details Synthetic peptide lung surfactants having covalently bonded anti Synthetic peptide lung surfactants having covalently bonded anti

1996-12-26

1999-03-23

Davenport, Avis M.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Chemical modification or the reaction product thereof, e.g.,...

530330, 530331, A61K 3800, C07K 500, C07K 700

Patent

active

058861564

ABSTRACT:
Synthetic pulmonary surfactants having antioxidant properties consisting of a complex of a polypeptide of 3-4 amino acid residues, with an antioxidant moiety, and a lipid consisting of one or more of the lipids associated with natural pulmonary surfactant were prepared. These surfactants are useful in the treatment of respiratory distress syndrome.

REFERENCES:
patent: 4861756 (1989-08-01), Jackson
patent: 5623052 (1997-04-01), McLean et al.
McLean et al., J. of Pharm & Exp. Therap, vol. 266, No. 2, pp. 551-556, 1993.
McLean, et al., Am. Phys. Society, pp. L292-L300, 1992.

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