Synthetic peptide lung surfactants having covalently bonded anti

Details Synthetic peptide lung surfactants having covalently bonded anti Synthetic peptide lung surfactants having covalently bonded anti

1995-07-14

1997-04-22

Davenport, Avis M.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

4 to 5 amino acid residues in defined sequence

530331, A61K 3800, C07K 500, C07K 700

Patent

active

056230524

ABSTRACT:
Synthetic pulmonary surfactants having antioxidant properties consisting of a complex of a polypeptide of 3-4 amino acid residues, with an antioxidant moiety, and a lipid consisting of one or more of the lipids associated with natural pulmonary surfactant were prepared. These surfactants are useful in the treatment of respiratory distress syndrome.

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Cochrane, et al., Science, ol. 254:566-568 (1991).
Waring, et al., Peptide Research 2(5):308-323 (1989).
McLean, et al., The Journal of Pharmacology and Experimental Therapeutics, vol. 266, No. 2, pp. 551-556 (1993) "Role of the Hydrophobic Face of Amphiphathic Alpha-Helical Peptides in Synthetic Pulmonary Surfactants".

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