Synthetic peptide, inhibitor to DNA viruses

Details Synthetic peptide, inhibitor to DNA viruses Synthetic peptide, inhibitor to DNA viruses

2008-07-15

2008-07-15

Campell, Bruce R. (Department: 1648)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

C530S327000, C530S328000, C530S330000, C424S134100, C424S229100, C424S230100

Reexamination Certificate

active

10745876

ABSTRACT:
The present invention relates to the identification of the active domain of Herpoxin, a DNA virus-inhibiting-protein which was isolated from cobra venom in U.S. Pat. No. 5,648,339 and has a molecular weight of 13.5 kDa We have isolated a fragment of Herpoxin which contains the active domain and which we have named Herp. Herp mimics the activity of Herpoxin in inhibiting the replication of DNA viruses. A synthetic version of the active fragment was produced having the amino acid sequence Asn-Leu-Tyr-Gln-Phe-Lys-Asn-Met-Ile-Gln. The synthetic version of Herp consisting of ten amino acids inhibits the replication of DNA viruses such as herpes viruses types 1 and 2, cytomegalovirus and varicella zoster virus as well asTubercle bacilli.

REFERENCES:
patent: 5648339 (1997-07-01), Lipps et al.
patent: WO 00/58495 (2000-10-01), None
Joubert et al Purification, Some Properties and Amino-Acid Sequences . . . from Najamja Kaouthia EurJBiochem 112,493-499 (1980).

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