Synthetic peptide endowed with immunological activity, capable o

Details Synthetic peptide endowed with immunological activity, capable o Synthetic peptide endowed with immunological activity, capable o

1989-07-24

1992-07-14

Wax, Robert A.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

530350, 530363, 530380, 424 88, 435 697, C07K 1300, A61K 3700

Patent

active

051304155

ABSTRACT:
A synthetic peptide endowed with immunological activity is disclosed, which is capable of inducing in mammals the formation of anti-peptide antibodies capable of recognizing human alpha-fetoprotein and of reacting with it, and incapable of recognizing albumin or its degradation products, with said peptide being essentially constituted by the aminoacidic sequence of formula (I), corresponding to 38-119 region of human alpha-fetoprotein.
Furthermore, the methods and means for preparing said peptide by means of the recombinant DNA techniques are reported.
The synthetic peptide (I), like the polyclonal and monoclonal antipeptide antibodies are particularly suitable for the early diagnosis of hepatocellular carcinoma and of teratocarcinoma.

REFERENCES:
patent: 4223002 (1980-09-01), Newman
Morinaga et al. (1983) Proc. Natl. Acad. Sci. 80, 4604-4608.
Nicosia et al. (1987) Infect. and Immun. 55, 963-967.
Maniatis et al. (1982) "Molecular Cloning; A Laboratory Manual", CSH, New York, pp. 403-433.

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