Synthetic peptide compositions with immunoreactivities to antibo

Details Synthetic peptide compositions with immunoreactivities to antibo Synthetic peptide compositions with immunoreactivities to antibo

1995-06-01

1997-10-28

Nucker, Christine M.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

435974, 530325, C12Q 170

Patent

active

056816960

ABSTRACT:
The present invention relates to a method for the detection HTLV-I and/or HTLV-II reactive antibodies and diagnosis of ATL (adult T cell leukemia/lymphoma) condition by the use of chemically synthesized peptide compositions. The peptide compositions comprise peptides having amino acid sequences corresponding to transmembrane and external segments of the envelope protein of HTLV-I/HTLV-II and mixtures thereof. The peptide compositions are highly immunoreactive with antibodies to HTLV in sera. The present invention further relates to a method for the simultaneous detection and diagnosis of ATL, HTLV-I and/or HTLV-II infection and Acquired Immune Deficiency Syndrome (AIDS) by the use of chemically synthesized HTLV peptide compositions in conjunction with a chemically synthesized HIV (1 and 2) peptide composition. The present invention also provides a simple method to differentiate between HTLV-I and HTLV-II infections.
The detection method includes an enzyme-linked immunosorbent assay (ELISA), an immunoradiometric assay (IRMA), and other forms of immunoassay procedures such as enzyme immuno blotting assay on nitrocellulose paper and an agglutination assay using the peptide composition as the antigen. The preferred detection method is ELISA.

REFERENCES:
patent: 4735896 (1988-04-01), Wang et al.
patent: 4833071 (1989-05-01), Wang et al.
patent: 4879212 (1989-11-01), Wang et al.
patent: 5066579 (1991-11-01), Reyes
patent: 5194586 (1993-03-01), Maeda et al.
patent: 5378805 (1995-01-01), Lal
patent: 5516632 (1996-05-01), Palker et al.
B.J. Poiesz., et al., Proc. Natl Acad. Sci. USA., 77:7415-19 (1980).
B.J. Poiesz., F.W. Ruscettti, M., S. Reitz., V. S. Kalyanaraman, R. Gallo, Nature (London) 294:268-71 (1981).
R.C. Gallo et al., Proc. Natl. Acad. Sci. USA., 79:5680-83 (1982).
M. Essex at al., Science, 221: 1061-63 (1983).
P. Clapham, K. Napy, R. A. Weiss, Proc. Natl. Acad. Sci. 81:2886-89 (1984).
R.C. Gallo et al., Cancer Res., 43:3892-99 (1983).
M.S. Reitz and R.C. Gallo, Cancer Surveys, 4:313-29 (1985).
W.A. Blattner, K. Tokatsuki, R. C. Gallo, J. Am. Med. Assoc., 250:1074-80 (1983).
K. Takatsuki, J. Uchiyama, K. Sagawa, J. Yodoi, Topics in Hematology, S. Seno, F. Takaku, S. Irino, Eds. (Excerpta Medica, Amsterdam, 1977) pp. 73-77.
W. A. Blattner et al., Int. J. Cancer, 30:257-64 (1982).
D. Catovsky et al., Lancet, 1982, 639-43 (1982).
D. W. Blayney et al., J. Am. Med. Assoc., 250:1048-52 (1983).
M. Robert-Guroff, F. W. Ruscetti, L. W. Posner, B. J. Poiesz, R.C. Gallo, J. Exp. Med., 154:1957-64 (1981).
R.C. Gallo et al., Proc. Natl. Acad. Sci. USA., 79:5680-83 (1981).
M. Robert-Guroff et al., J. Exp. Med., 157:248-58 (1983).
M. Shimoyama et al, Jpn. J. Clin. Oncol., 12:109-16 (1982).
M. Seiki, S. Hattori, Y. Hirayama, M. Yoshida, Proc. Natl. Acad. Sci. USA., 80:3618-22 (1983).
Saxinger, C.W. et al., Science, 225:1473-76 (1984).
Samuel, K.P. et al., Science, 226:1094-97 (1984).
Wang, J.J-G, Steel, S., Wisniewolski, R. and Wang, C.Y., Proc. Natl. Acad. Sci. USA, 83:6159-63 (1986).
Liu, Fu-Tong et al., Biochemistry, 18:690-97 (1979).
V. S. Kalyanaraman, M. G. Sarngadharan, M. Robert-Guroff et al., Science, 218:571-73 (1982).
J. D. Rosenblatt et al., N. Engl. J. Med., 315:372-77 (1986).
M. Robert-Guroff, S. H. Weiss, J. H. Giron et al., J. Am. Med. Assoc., 255:3133-37 (1986).
H. Lee, P. Swanson, V. S. Shorty et al., Science, 244:471-75 (1989).
R. C. Gallo, Med. Oncol. Tumor Pharmacother., 3:265-67 (1986).
K. Shimotohno, Y. Takahashi, et al., Proc. Natl. Acad. Sci. USA., 82:3101-05 (May 1985).
J. Sodroski, R. Patarca, D. Perkins et al., Science, 225:421 (1984).
G. M. Shaw, M. A. Gonda, G. H. Flickinger et al., Proc. Natl. Acad. Sci. USA., 81:4544-48 (1984).
S. G. Sandler, C. Fang, in Transfusion-Transmitted Viral Disease, Arlington, VA:American Assn. of Blood Bankers, pp. 19-35 (1987).

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