Synthetic peptide and its uses

Details Synthetic peptide and its uses Synthetic peptide and its uses

1995-05-16

1998-06-02

Spiegel, Carol A.

Chemistry: analytical and immunological testing

For preexisting immune complex or auto-immune disease

Immune complex

436518, 435 792, 530325, 530326, 530327, 530328, 530413, G01N 33564

Patent

active

057598630

ABSTRACT:
The invention provides a fragment of C1q which is characterized in that a plurality of such fragments selectively binds immune complexes or aggregated immunoglobulins in the presence of monomeric immunoglobulin. The invention also provides a synthetic peptide comprising the sequence: ##STR1## or variants thereof capable of binding immunoglobulin. Like the C1q fragment, a plurality of the peptides can selectively bind immune complexes or aggregated immunoglobulins in the presence of monomeric immunoglobulin. As a result of this property, the fragments and peptides are well-adapted for removing immune complexes and aggregated immunoglobulins from fluids containing monomeric immunoglobulin, and for detecting or quantitating immune complexes in such fluids. The invention also provides a binding material for removing immune complexes or aggregated immunoglobulins from a fluid. The binding material comprises plural binding peptides, the peptides being characterized in that a plurality of them selectively binds immune complexes and aggregated immunoglobulins in the presence of monomeric immunoglobulin.

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