Synthetic peptide analogs of cross-linked N-telopeptides of type

Details Synthetic peptide analogs of cross-linked N-telopeptides of type Synthetic peptide analogs of cross-linked N-telopeptides of type

1997-02-26

1998-10-06

Tsang, Cecilia J.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

8 to 10 amino acid residues in defined sequence

530356, 435 791, 435 793, C07K 700, C07K 706, G01N 3353, G01N 33531

Patent

active

058177558

ABSTRACT:
Synthetic linear peptides embodied by Xaa-Tyr-Xaa-Gly-Xaa-Gly-Val-Gly which mimic the epitope recognized by mAb 1H11 (ATCC No. HB 10611) in cross-linked N-telopeptides of type I collagen (NTx).

REFERENCES:
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patent: 5140103 (1992-08-01), Eyre
patent: 5300434 (1994-04-01), Eyre
patent: 5320970 (1994-06-01), Eyre
Bonde, Martin, et al., "Immunoassay for quantifying type I collagen degradation products in urine evaluated," Clin Chem., 40(11):2022-2025, 1994.
Clemens, et al., "Characteristics of a specific immunoassay for bone resorption based on crosslinked N-telopeptides of bone collagen," Clinical Chemistry, 39(6):1247-1248, 1993.
Otter, et al., "Conformational analysis of the type II and III collagen .alpha.-I chain N-telopeptides by proton-NMR spectroscopy and restrained molecular mechanics calculations," Chemical Abstracts, 119:352, 1993.

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