Synthetic oligonucleotides which mimic telomeric sequences for u

Details Synthetic oligonucleotides which mimic telomeric sequences for u Synthetic oligonucleotides which mimic telomeric sequences for u

1995-01-31

1997-07-01

Elliott, George C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

424 9321, 435375, 536 231, A61K 4800, C12N 510, C07H 2104

Patent

active

056438907

ABSTRACT:
A method of inhibiting proliferation of immortal cells or cells that express telomerase is disclosed. The method includes introduction of synthetic oligonucleotides which mimic telomere motifs. Quite surprisingly applicant has demonstrated that a single telomere motif, TTAGGG exhibits greater cellular uptake and higher inhibition of proliferation than longer oligonucleotides, which were previously thought to be necessary to achieve sequence specific interaction with telomerase.

REFERENCES:
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Zahler, Alan et al., "Inhibition Of Telomerase By G-Quartet DNA Structures", 1991, Nature, vol. 350, p. 718-720.
Blackburn, Elizabeth, "Structure And Function Of Telomeres", 1991, Nature, vol. 350, p. 569-5973.
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Blackburn, Elizabeth, "Telomeres", 1991, TIBS.
"Chromosome Ends Catch Fire", Sep. 1994, Science, vol. 265, p. 16561658.
Romero, Daniel et al., 1991, "A Conserved Secondary Structure For Telomerase RNA", Cell, vol. 67, 343-353.
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Greider, 1990, Telomeres, Telomerase And Senescence, BioEssays, vol. 12, No. 8, pp. 363-369.
Prowse, 1993, Identification Of A Nonprocessive Telomerase Activity From Mouse Cells, Proc. Natl. Acad. Sci. USA, vol. 90, pp. 1493-1497, Feb. 1993.
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