Synthetic oligonucleotides as inducers of erythroid...

Details Synthetic oligonucleotides as inducers of erythroid... Synthetic oligonucleotides as inducers of erythroid...

2007-08-28

2007-08-28

McGarry, Sean (Department: 1635)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C536S023100, C536S024100, C536S024500, C435S006120, C435S375000, C435S377000

Reexamination Certificate

active

10220310

ABSTRACT:
The invention refers to a synthetic double-stranded oligonucleotide having a length comprised between 10 and 50 bases and a nucleic acid sequence selected from the group consisting of: (a) sequences corresponding to a selected portion of the promoter of human γ-globin gene; and (b) sequences corresponding to a selected portion of the human genomic region comprised between the γ-globin gene and the δβ-cluster, for use as an inducer of erythroid differentiation.

REFERENCES:
patent: 5763488 (1998-06-01), Bemis et al.
patent: 6022738 (2000-02-01), Atweh
patent: WO96/40271 (1996-12-01), None
patent: WO9712042 (1997-04-01), None
Agrawal et al. Antisense therapeutics: is it as simple as complementary base recognition? 2000 Mol. Med. Today: Reviews. vol. 61, pp. 72-81.
Opalinska et al. Nucleic acid therapeutics: basic principlese and recent applications. 2002 Nature Reviews: Drug Discovery vol. 1, pp. 503-514.
Jen et al. Suppression of gene expression by targeted disruption of messenger RNA: available options and current strategies 2000 Stem Cells vol. 18, pp. 307-319.
Crooke, S. Progress in antisense technology 2004 Annu. Rev. Med. vol. 55, pp. 61-95.
Madalyn Castle et al.; Blood, vol. 82, No. 4, pp. 1344-1350, Aug. 15, 1993. See PCT search report.
Wendy Magis et al.; Biochem. Biophys. Res. Commun.; vol. 214, No. 3, pp. 927-933, Sep. 25, 1995. See PCT search report.
G. Joan Grindlay et al.; Nucleic Acids Research; vol. 12, No. 4, pp. 1811-1820, 1984. See PCT search report.
Scott D. Langdon et al.; Blood, vol. 91, No. 1, pp. 309-318, Jan. 1, 1998. See PCT search report.
J. DeSimone et al.; Proc. Natl. Acad. Sci. USA, vol. 79, pp. 4428-4431, Jul. 1982, “5-Azacytidine Stimulates Fetal Hemoglobin Synthesis in Anemic Baboons”.
C. H. Lowrey, et al.; The New England Journal of Medicine, vol. 329; pp. 845-848, Sep. 16, 1993, No. 12 Next; “Treatment With Azacitidine of Patients With End-Stage β-Thalassemia”.
S. P. Perrine et al.: The New England Journal of Medicine, vol. 328; pp. 81-86; Jan. 14, 1993; A Short-Term Trial of Butyrate to Stimulate Fetal-Globin-Gene Expression in the β-Globin Disorders.
G.P. Rodgers et al.: The New England Journal of Medicine; vol. 328, pp. 73-80; Jan. 14, 1993, No. 2 Next; “Augmentation by Erythropoietin of the Fetal-Hemoglobin Response to Hydroxyurea in Sickle Cell Disease”.
Rodgers et al—British Journal of Haematology vol. 91, pp. 263-268, (1995); “Novel Treatment Options in the Severe β-Globin Disorders”.
S. Torkelson, et al.: Blood Cells, Molecules, and Disease (1996) 22(14) Jul. 31: pp. 150-158; “Erythroid Progenitor Proliferation is Stimulated by Phenoxyacetic and Phenylalkyl Acids”.
J. Rochette et al.: Blood Reviews (1994) vol. 8; pp. 213-224; “Fetal Hemoglobin Levels in Adults”.
O. Nakajima et al.: Federation of European Biochemical Societies, Sep. 1993), vol. 330, No. 1, pp. 81-84: “Enhancement by Retinoid of Hemin-Induced Differentiation of Human Leukemia K562 Cell Line”.
N. Bianchi et al.: British Journal of Haematology, (1999), vol. 104; pp. 258-265: “The DNA-binding Drugs Mithramycin and Chromomycin are Powerful Inducers of Erythroid Differentiation of Human K562 Cells”.
S. Castaigne, et al.: Blood, vol. 76, No. 9, Nov. 1, 1990: pp. 1704-1709: “All-Trans Retinoic Acid as Differentiation Therapy for Acute Promyelocytic Leukemia. I. Clinical Results”. The New England Journal of Medicine, vol. 327, No. 8, Aug. 20, 1992, pp. 569-570.
T. Ikuta et al.: Annals of New York Academy of Sciences; pp. 87-99: “Cellular and Molecular Effects of a Pulse Butyrate Regimen and New Inducers of Globin Gene Expression and Hematopoiesis”.
C. B. Lozzio et al.: Blood, vol. 45, No. 3 (Mar.), 1975; pp. 321-334: “Human Chronic Myelogenous Leukemia Cell-Line With Positive Philadelphia Chromosome”.
R. Gambari, et al.: Experientia 41 (1985), pp. 673 & 675; Birkhäuser Verlag, CH-4010 Basel/Switzerland; “Efficient Cell Proliferation and Predominant Accumulation of ε-globin mRNA in human Leukemic K562 Cells Which Produce Mostly Hb Gower 1”.
R. Gambari, et al.: Cell Differentiation, 14 (1984) pp. 87-97; Elsevier Scientific Publishers Ireland, Ltd.; pp. 87-97: “Human Leukemia K-562 Cells: Induction of Erythroid Differentiation by 5-azacytidine”.
Rutherford R.E. Gale et al.: Nature, vol. 280, Jul. 12, 1979, pp. 164-165: “K562 Human Leukaemic Cells Synthesise Embryonic Haemoglobin in Response to Haemin”.
Sambrook et al. Molecular Cloning—2nd edition Extraction, Purification, and Analysis of Messenger RNA from Eukaryotic Cells, 7.43-7.45: “Electrophoresis of RNA through Gels Containing Formaldehyde”.
R. Cortesi et al.: European Journal of Haematology (1998), 61, pp. 295-301: “Human Leukemic K562 Cells Treated With Cytosine Arabinoside: Enhancement of Erythroid Differentiation by Retinoic Acid and Retinol”.
Holland et al.: Proc. Natl. Acad. Sci., USA, vol. 88, pp. 7276-7280, Aug. 1991, Biochemistry: “Detection of Specific Polymerase Chain Reaction Product by Utilizing the 5′→3′ Exonuclease Activity ofThermus aquaticusDNA polymerase”.
Al-Khatti et al.: Concise Report, Blood, vol. 72, No. 2 (Aug. 1988); pp. 817-819: “Cooperative Enhancement of F-Cell Formation in Baboons Treated With Erythropoietin and Hydroxyurea”.
Wolfgang Pfleiderer, et al.: Nucleic Acids Research, Symposium Series No. 7, 1980; pp. 61-71.

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