Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 15 to 23 amino acid residues in defined sequence
Patent
1987-12-14
1990-05-29
Lee, Lester L.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
15 to 23 amino acid residues in defined sequence
530328, 530324, 530858, C07K 706, C07K 708
Patent
active
049297180
ABSTRACT:
The invention relates to a novel immunogenic synthetic peptide that is capable of specifically blocking potassium channels of excitable membranes and inducing immunity against an effective lethal dose of Noxiustoxin. The invention also relates to the discovery that the immunogenic and blocking properties of the peptide are severable. Peptides possessing either the immunogenic or the blocking property are disclosed.
REFERENCES:
patent: 4499080 (1985-02-01), Duflot et al.
L. D. Possani et al., Carlsburg Res. Commun., "Primary Structure of Noxiustoxin", 47: 285-289, 1982.
Anthony T. Tu, Marcel Dekker, Inc. New York & Basel, "Handbook of Natural Toxins",m 2: 513-543.
Fletcher B. Taylor, Jr., et al., Thrombosis Research, "Clots Lysis: Effects of Protein C", 37: 639-649, 1985.
Hector H. Valdiva, et al., Elsevier Science Publishers B.V. (Biomedical Divison) "FEBS Letters", 226(2); 280-284, 1988.
E. Carbone, et al., European Journal of Physiology, "Blocking of the Squid Axon L+ Channel by Noxiustoxin", 408: 423-431, 1987.
Maria Sitges, et al., The Journal of Neuroscience, "NTX-Induced Transmitter Release and K+ Permeability", 6(6): 1570-1574, 1986.
Bayon Marco A. A. C.
Gurrola Georgina B.
Possani Lourival D. P.
Sitges Maria B.
Lee Lester L.
Universidad Nacional Autonoma De Mexico
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