Synthetic nonapeptide for use as an adjuvant

Details Synthetic nonapeptide for use as an adjuvant Synthetic nonapeptide for use as an adjuvant

1988-02-12

1993-04-27

Lee, Lester L.

Drug, bio-affecting and body treating compositions

Lymphokine

514 15, 530328, C07K 706

Patent

active

052060144

ABSTRACT:
The specification relates to a synthetic peptide converted into a salt comprising one or more amine groups and capable of potentiating in vivo the primary and secondary antibody response to thymo-dependent and thymo-independent antigens having low immunogenicity.
Injectable preparations comprising a solution of the peptide in a pharmacologically acceptable solvent are particularly useful as adjuvants in therapy.

REFERENCES:
patent: 4283328 (1981-08-01), Stammer
patent: 4774320 (1988-09-01), Tagliabue et al.
patent: 4845079 (1989-07-01), Luly et al.
March et al. Nature (1985) 315:641-647.
Auron et al. Proc. Nat. Acad. Sci. (1984) 81:7907-7911.
Bensi et al. Gene. (1987) 52:95-101.
Clark et al. Nucleic Acids Res. (1986) 14:7897-7914.

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