Synthetic multivalent sLe.sup.x containing polylactosamines and

Details Synthetic multivalent sLe.sup.x containing polylactosamines and Synthetic multivalent sLe.sup.x containing polylactosamines and

1996-09-27

1999-10-12

Fonda, Kathleen K.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 172, 536 187, 514 25, A61K 31715

Patent

active

059655445

ABSTRACT:
The present invention is directed to novel compositions and their use in the treatment of inflammatory responses. Specifically, the invention is directed to novel synthetic oligosaccharide constructs, especially multiple sLe.sup.x decorated poly-N-acetyllactosamines and their use to block lymphocyte binding to correspondent oligosaccharides on the endothelial surface, and thus reduce or otherwise ameliorate an undesired inflammatory response and other disease states characterized by lymphocyte binding. Furthermore the invention is directed to the use of the novel saccharides to block bacterial adherence to endothelium and thus prevent and/or treat bacterial infections. A further use of the present invention lies in the field of cancer treatment where metastasis of sLe.sup.x -positive tumor cells is inhibited by these glycans.

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