Synthetic molecules having immune activity

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C514S025000

Reexamination Certificate

active

07989602

ABSTRACT:
The present invention is directed to synthetic molecules having biological activity similar to PIM (acyl glycerol phosphatidylinositol manno-oligosaccharide) activity, for use in the treatment and prevention of inflammatory or immune cell mediated diseases or disorders.

REFERENCES:
patent: 06271579 (1994-06-01), None
patent: 06271597 (1994-09-01), None
patent: WO 94/21656 (1994-09-01), None
patent: WO 0202140 (2002-01-01), None
Sanderson et al. The Journal of Biological Chemistry, vol. 237, No. 12, Dec. 1982, pp. 3603-3613.
Bennett, C.F. et al. 1997 “An ICAM-1 antisense oligonucleotide prevents and reverses dextran sulfate sodium-induced colitis in mice”J Pharmacol Exper Ther280:988-1000.
Crossman, A. et al. 1997 “Parasite glycoconjugates. Part 7. Synthesis of further substrate analogues of early intermediates in the biosynthetic pathway of glycosylphosphatidylinositol membrane anchors”J Chem Soc, Perkin Trans1:2769-2774.
Dreef C.E. et al. 1991 “Synthesis of 5-phosphonate analogues of myo-inositol 1,4,5-trisphosphate: possible intracellular calcium antagonists”Tetrahedron Letters32:6021-6024.
Erb K.J. et al .1998 “Infection of mice withMycobacterium bovis-Bacillus Calmete-Guérin (BCG) suppresses allergen-induced airway eosinophilia”J Exp Med187:561-569.
Gigg, J. et al. 1985 “Synthesis of propyl 4-O-(3,6-Di-O-methyl-β-D-glucopyranosyl)-2,3-di-O-methyl-α-D-rhamnopyranoside”Carbohydrate Res141:91-97.
Gilleron, M. et al. 2001 “Acylation state of the phosphatidylinositol manosides fromMycobacterium bovisBacillus Calmette Guérin and ability to induce granuloma and recruit natural killer T cells”J Biol Chem276:34896-34904.
Gilleron, M et al. 2003 “Acylation state of the phosphatidylinositol hexamannosides fromMycobacterium bovisBacillus Calmette Guérin andMycobacterium tuberculosisH37Rv and its implication in Toll-like receptor response”J Biol Chem278:29880-29889.
Green, M.M. et al. 1987 “Broken worm and wormlike models for polyisocyanates”Macromolecules20:2636-2638.
Gross, D. M. et al. 1998 “Identification of LFA-1 as a candidate autoantigen in treatment-resistant lyme arthritis”Science281:703-706.
Halloran, M.M. et al. 1996 “Cellular adhesion molecules in rat adjuvant arthritis”Arthritis and Rheumatism39:810-819.
Hasegawa, Y. et al. 1994 “Prevention of autoimmune insulin-dependent diabetes in non-obese diabetic mice by anti-LFA-1 and anti-ICAM-1 mAB”Int Immunol6: 831-838.
Herold, K.C. et al. 1994 “Prevention of autoimmune diabetes by treatment with anti-LFA-1 and anti-ICAM-1 monoclonal antibodies”Cellular Immunol157:489-500.
Herz U et al. 1998 “BCG infection suppresses allergic sensitization and development of increased airway reactivity in an animal model”J Allergy Clin Immunol102:867-874.
Hirooka M. et al. 2003 “Glycosylation using hemiacetal sugar derivatives: synthesis of O-α-D-rhamnosyl-(1→3)-O-α-D-rhamnosyl-(1→2)-D-rhamnose and )-α-D-Tyvelosyl-(1→3)-O-α-D-mannosyl-(1→4)-L-rhamnose” Bull Chem Soc Jpn 76:1409-1421.
Hirth G et al. 1982 “Synthesis of glyceryletherphosphatides. Part 1. Preparation of 1-O-octadecyl-2-O-acetyl-sn-glyceryl-3-phosphorylcholine (‘platelet activating factor’), its enantiomers and some analogous compounds” Helvetica Chemica Acta 65:1059-1084.
Hirth G et al. 1983 “Synthesis of glyceryletherphosphatides. Part 2. Preparation of 2-O-acetyl-1-O-[(Z)-9-octadecenyl]-sn-glyceryl-3-phosphorylcholine (Oleyl-PAF'), of its enantiomer and some analogous, unsaturated compounds”Helvetica Chimica Acta66: 1210-1240.
Iranpoor, N. et al .1996 “FeCI3-6H20 supported on SiO2 catalyzed ring-opening of epoxides with alchols, acetic acid, water, chloride, bromide, and nitrate ions”Synthesis: 1473-1476.
Itano K. et al .1980 “Stereospecific preparation of monoglucosides of optically activetrans-1,2-cyclohexanediiols by enzymic trans-D-glucosylation and13C-N.M.R. spectroscopy of the resulting mono-D-glucopyranosides”Carbohydrate Res87:27-34.
Kakimoto, K. et al. 1992 “The effect of anti-adhesion molecule antibody on the development of collagen-induced arthritis”Cellular Immunol142:326-337.
Knoerzer, D.B. et al. 1997 “Clinical and histological assessment of collagen-induced arthritis progression in the diabetes-resistant BB/Wor Rat”Toxicol Pathol25:13-19.
Koizumi, K. et al. 1991 “Characterization of five isomers of branched cyclomaltoheptaose (βCD) having degree of phoymerization (d.p.) = 9: Reinvestigation of three positional isomers of diglucosyl-βCD”Carbohydrate Res215:127-136.
Koto, S. et al. 1976 “Preparation of 2,3,4,6-tetra-O-benzyl-D-mannose”Bull Chem Soc of Jpn49:2639-2640.
Koto, S. et al. 1992 “Dehydrative glycosylation using heptabenzyl derivatives of glucobioses and lactose”Bull Chem Soc Jpn65:3257-3274.
Lindberg, J. et al. 2002 “Efficient synthesis of phospholipids from glycidyl phosphates”J Org Chem67:194-199.
Lindhorst, T.K. et al. 2000 “Cluster mannosides as inhibitors of type 1 fimbriae-mediated adhesion ofEscherichia coli: pentaerythritol derivatives as scaffolds” Eur J Org Chem 2027-2034.
Mulligan, M.S. et al. 1995 “Comparmentalized roles for leukocytic adhesion molecules in lung inflammatory injury”J Immunol154:1350-1363.
Oppenheimer-Marks, N. et al. 1998 “Interleukin 15 is produced by endothelial cells and increases the transendothelial migration of T-cells in vitro and in the SCID mouse-human rheumatoid arthritis model in vivo”J Clin Invest101:1261-1272.
Rajanbabu, T.V. et al. 1989 “Stereochemical control in hex-5-enyl radical cyclizations: from carbohydrates to carbocycles”J Am Chem Soc111:1759-1769.
Randolph D.A. et al. 1999 “Cooperation between Th1 and Th2 cells in a murine model of eosinophilic airway inflammation”J Clin Invest104:1021-1029.
Schimmer, R.C. et al. 1998 “Streptococcal cell wall-induced arthritis: requirements for IL-4, IL-10, IFN-γ, and monocytes chemoattractant protein-1”J Immunol160:1466-1471.
Severn, W.B. et al. 1997 “Improved procedure for the isolation and purification of lipoarabinomannan fromMycobacterium bovisstrain AN5”J Microbiol Meth28:123-130.
Van Boeckel C.A.A. et al. 1979 “Synthesis of glucosyl phosphatidylglycerol via a phosphotriester intermediate”Tetrahedron Letters37:3561-3564.
Van Boeckel C.A.A. et al. 1981 “Phosphotriester approach to the synthesis of β-glucosylated mono and diphosphatidyl glycerols: bacterial cell wall components” Tetrahedron 37:3751-3761.
Watanabe Y. et al. 1993 “Glycosylation based on phosphite chemistry”Synlett, 115-116.
Watanabe Y. et al. 1994 “Glycosylation using glycosyl phosphite as a glycosyl donor”Tetrahedron50:6523-6536.
Zalipsky S. et al .1999 “New chemoenzymatic approach to glycol-lipopolymers: practical preparation of functionally active galactose-poly(ethylene glycol)-distearoylphosphatidic acid (Gal-PEG-DSPA) conjugate”Chem Commun7:653-654.
Zalipsky S et al. 2002 “Phospholipase D mediated synthesis of PEG-lipids for liposomal drug delivery”Polymer Preprints43:710.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Synthetic molecules having immune activity does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Synthetic molecules having immune activity, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Synthetic molecules having immune activity will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2745787

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.