Synthetic molecules for labeling histidine-rich proteins

Details Synthetic molecules for labeling histidine-rich proteins Synthetic molecules for labeling histidine-rich proteins

2006-05-09

2006-05-09

Solola, Taofiq (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

C549S391000

Reexamination Certificate

active

07041821

ABSTRACT:
The invention provides Zn-chelating compounds that are molecularly engineered to bind to a specific target sequence in a protein of interest. The Zn2+ion is far less toxic and promiscuous than nickel and therefore provides an attractive alternative to Ni-based labeling systems. Invention Zn-chelating compounds also do not require oxidizable thiols and therefore can be used in non-reducing environments such as the surface of living cells. In addition, the target sequence is genetically encodable and requires incorporation of only a few amino acids, unlike fusions to fluorescent proteins such as GFP.

REFERENCES:
patent: 5262333 (1993-11-01), Heiman et al.

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