Synthetic methods for the preparation of indolyquinones

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

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548460, 548469, 548492, 548494, C07D20902

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active

057864888

ABSTRACT:
The present invention relates to novel synthetic methods for the preparation of indolylquinones. The methods of the present invention are directed to synthetic reactions involving indoles and halo-quinones in solvent and in the presence of a metal carbonate. The invention also relates to bis- and mono-indolylquinones of high purity and pharmaceutical compositions containing the same.

REFERENCES:
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Arai et al., Chem Pharm., Bull. 29(4), pp. 1005-1012, 1981.
Sekita, Chem. Pharm. Bull. 31(9), pp. 2998-3001, 1983.
Horcher et al., Liebigs Ann. Chem., pp. 1765-1771, 1986 (with translation).
Arai et al. Chem. Pharm., Bull. 38(11), pp. 2929-2932, 1990.
Kaji et al., Chem. Pharm., Bull. 43(10), pp. 1818-1820, 1995.

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