Synthetic methodology for the reductive alkylation at the...

Details Synthetic methodology for the reductive alkylation at the... Synthetic methodology for the reductive alkylation at the...

2007-10-16

2007-10-16

Anderson, Rebecca (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

11014657

ABSTRACT:
A process for the reductive alkylation at the C-3 position of an indole compound in which the indole is treated with an aldehyde in the presence of a Lewis acid and a silicon hydride reducing agent. The process is useful for alkylating the C-3 position of indoles that contain acid-sensitive substituents at the N-1 position.

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