Synthetic method for ethynylation of aromatic compounds

Organic compounds -- part of the class 532-570 series – Organic compounds – Oxygen containing

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568426, 568433, C07C 4561, C07C 4500

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053211650

ABSTRACT:
A method of producing an ethynyl aromatic aldehyde comprises reacting a protected copper(I) acetylide salt with a halogen substituted aromatic compound to produce a protected ethynyl aromatic aldehyde.
The protected ethynyl aromatic aldehyde may be deprotected to yield an acetylene terminated aromatic aldehyde which is useful for making acetylenic Schiff's base monomers and conductive polymers thereof.

REFERENCES:
patent: 3996290 (1976-12-01), Tavares et al.
patent: 4010207 (1977-03-01), Hall et al.
Austin, W. B. et al., "Facile Synthesis of Ethynylated Benozic Acid Derivves and Aromatic Compounds via Ethynyltrimethylsilane," Journal of Organic Chemistry, vol. 46, No. 11 (1981), pp. 2280-2286.
Dawson, D. J. et al., "Cocyclotrimerization of Aryl Acetylenes: Substituent Effects on Reaction Rate," American Chemistry Society Symposium Series:Polymers for High Technology, vol. 346, ch. 38 (1987), pp. 445-456.
Stephens, R. D. et al., "The Substitution of Aryl Iodides with Cuprous Acetylides, A Synthesis of Tolanes and Heterocyclics," Journal of Organic Chemistry, vol. 28 (Dec. 1963), pp. 3313-3315.
Castro, C. E. et al., "Copper (II) Substitutions, Scope and Mechanism of Cuprous Acetylide Substitutions", Journal of the American Chemical Society, vol. 91 (Nov. 5, 1969), pp. 6464-6470.
Onopchenko, A. et al., "Selective Catalytic Hydrogenation of Aromatic Nitro Groups in the Presence of Acetylenes, Synthesis of (3-Amino-phenyl) acetylene via Hydrogenation of Dimethylcarbinol Substituted (3-Nitrophenyl) acetylene over Heterogeneous Metallic Ruthenium Catalyst," Journal of Organic Chemistry, vol. 44, No. 8 (1979).

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