Synthetic mammalian sulphamidase and genetic sequences encoding

Details Synthetic mammalian sulphamidase and genetic sequences encoding Synthetic mammalian sulphamidase and genetic sequences encoding

1997-06-13

1999-10-26

Wax, Robert A.

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

435195, 435188, 536 232, 5362523, 5363201, 530350, A61K 3847, C12N 914, C07H 2104, C07K 100

Patent

active

059723335

ABSTRACT:
The present invention relates generally to mammalian sulphamidase and to genetic sequences encoding same and to the use of these in the investigation, diagnosis and treatment of subjects suspected of or suffering from sulphamidase deficiency.

REFERENCES:
patent: 5298395 (1994-03-01), Park
Alberts, et al. (1989) "DNA Cloning and Genetic Engineering", Molecular Biology of The Cell, Second Edition, Chapter 5, Garland Publishing, Inc., New York, pp. 258-266.
Coulter II, et al. (1993) "Identification of Cortexin: A Novel, Neuron-Specific, 82-Residue Membrane Protein Enriched in Rodent Cerebral Cortex", Journal of Neurochemistry 61(2):756-759.
Freeman, et al. (1986) "Human Liver Sulphamate Sulphohydrolase", Biochem. J. 234:83-92.
Mahuran, et al. (1983) "A Rapid Four Column Purification of 2-Deoxy-D-Glucoside-2-Sulphamate Sulphohydrolase from Human Liver", Biochimica et Biophysica Acta 757:359-365.
Ford, C.F. et al. "Fusion tails for the recovery and purification of recombinant proteins." Protein Expression and Purification (Apr./Jun. 1991), vol. 2, No. 2/3, pp. 95-107.
O'Brien, J.S. et al. "Sanfilippo disease type B: enzyme replacement and metabolic correction in cultured fibroblasts." Science (Aug. 1973), vol. 181, No. 101, pp. 753-755.
Dean, M.F. et al. "Mobilization of glycosaminoglycans by plasma infusion in mucopolysaccharidosis type III--two types of response," Nature New Biology (May 1973), vol. 243, pp. 143-146.

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