Synthetic liposomes for enhanced uptake and delivery

Details Synthetic liposomes for enhanced uptake and delivery Synthetic liposomes for enhanced uptake and delivery

1994-11-10

1996-04-30

Kishore, Gollamundi S.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

4284022, 264 41, A61K 9127

Patent

active

055122957

ABSTRACT:
Liposomes are prepared comprising a polyhydroxybutyrate calcium polyphosphate complex which provides for uptake of a desired component, particularly nucleotides and nucleic acids. The charged species may be introduced into the lumen of a liposome by incubating liposomes with a solution of the component of interest for sufficient time to provide for introduction of the component into the lumen of the liposome, followed by washing at diminished temperatures. The resulting liposomes may then be used as vehicles for delivery of the lumen component.

REFERENCES:
Hug and Sleight, "Liposomes for the Transformation of Eukaryotic Cells", Biochem. Biophys. Acta. 1097:1-17 (1991).
Szoka, "Comparative Properties and Methods of Preparation of Lipid Vesicles (Liposomes)", Ann. Rev. Biophys. Bioeng. 9:467-508 (1980).
Wilson, Cell 17, p. 77 May 1979.
Ostro Archives of Biochem & Biophy. 201 #2 p. 392 1980.
Gao Biochem. Biophys Res. Comm. 179 #1 p. 280 1991.

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