Synthetic lipid mixtures for the preparation of a...

Details Synthetic lipid mixtures for the preparation of a... Synthetic lipid mixtures for the preparation of a...

2008-03-06

2010-11-30

Tate, Christopher R. (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C530S300000

Reexamination Certificate

active

07842664

ABSTRACT:
The invention relates to reconstituted surfactants consisting of artificial phospholipids and peptides able to lower the air-liquid surface tension, more particularly to reconstituted surfactants comprising special phospholipid mixtures and artificial peptides which are analogues of the natural surfactant SP-C protein for the treatment of respiratory distress syndrome (RDS) and other diseases relating to pulmonary surfactant dysfunctions.

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Palmblad, J. of Biochem., 1999, vol. 338, pp. 381-386.
Yu, Shou-Hwa et al., “Effect of plumonary surfactant protein B (SP-B) and calcium on phospholipid adsorption and squeez-out of phosphatidylglycerol from binary phospholipid monolayers containing dipalmitoylphosphatidylcholine” Biochimica Et Biophysica Acta. Netherlands, vol. 1126, No. 1, pp. 26-34, Jun. 5, 1992.
U.S. Appl. No. 12/422,581, filed Apr. 13, 2009, Johansson, et al.

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