Synthetic ion channels

Details Synthetic ion channels Synthetic ion channels

2006-10-31

2006-10-31

Weber, Jon (Department: 1653)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C530S300000, C530S350000, C530S333000, C530S402000

Reexamination Certificate

active

07129208

ABSTRACT:
The present invention relates to amphiphiles for the formation of a synthetic ion channel in a phospholipid bilayer or biomembrane. The synthetic channel selectively transports chloride ions across the phospholipid bilayer or the membrane. Said amphiphiles impart ion permeability to the phospholipid bilayers or biomembrane and also modulate cellular volume in mammalian cells in vitro.

REFERENCES:
patent: 5204239 (1993-04-01), Gitler et al.
patent: 5368712 (1994-11-01), Tomich et al.
patent: 5516890 (1996-05-01), Tomich et al.
patent: 5654274 (1997-08-01), Kari
patent: 6063594 (2000-05-01), Bandman et al.
patent: 6077826 (2000-06-01), Tomich et al.
patent: 6093567 (2000-07-01), Gregory et al.
patent: 6228616 (2001-05-01), Bandman et al.
patent: 6294350 (2001-09-01), Peterson
Abel, E. et al., Hydraphile Channels: Structural and Fluorescent Probes of Position and Function in a Phospholipid Bilayer, J. Am. Chem. Soc., (1999), pp. 9043-9052, vol. 121.
Akerfeldt, K.S. et al., Synthetic Peptides as Models for Ion Channel Proteins, Acc. Chem. Res. (1993), pp. 191-197, vol. 26.
Al-Awqati, Q., Chloride Channels of Intracellular Organelles, Current Opinion in Cell Biology, (1995), pp. 504-508, vol. 7.
Brandl, C.J. et al., Hypothesis About the Function of Membrane-Buried Proline Residues in Transport Proteins, Proc. Natl. Acad. Sci., (1986), pp. 917-921, vol. 83.
Clark, T.D. et al., Self-Assembling Cyclin β-Peptide Nanotubes as Artificial Transmembrane Ion Channels, J. Am. Chem. Soc., (1998), pp. 651-656, vol. 120.
Corringer, P-J et al., Mutational Analysis of the Charge Selectivity Filter of the α7 Nicotinic Acetylcholine Receptor, Neuron, (1999), pp. 831-843, vol. 22.
Das, S. et al., Proof for a Nonproteinaceous Calcium-Selective Channel inEscherichia coliby Total Synthesis from (R)-3-Hydroxybutanoic Acid and Inorganic Polyphosphate, Proc. Natl. Acd. Sci., (1997), pp. 9075-9079, vol. 94.
Dutzler, R. et al., X-ray Structure of a CIC Chloride Channel at 3.0 Å Reveals the Molecular Basis of Anion Selectivity, Nature, (2002), pp. 287-294, vol. 415.
Fahlke, C. et al., Pore-Forming Segments in Voltage-Gated Chloride Channels, Nature, (1997), pp. 529-532, vol. 390.
Fahlke, C. et al., Residues Lining the Inner Pore Vestibule of Human Muscle Chloride Channels, The Journal of Biological Chemistry, (2001), pp. 1759-1765, vol. 276:3.
Frizzell R.A. et al., Altered Regulation of Airway Epithelial Cell Chloride Channels in Cystic Fibrosis, Science, (1986), pp. 558-560, vol. 233.
Fyles, T.M. et al., Ion Channel Models, Comprehensive Supramol. Chem., (1996), pp. 53-77, vol. 10.
Galzi, J-L. et al., Mutations in the Channel Domain of a Neuronal Nicotinic Receptor Convert Ion Selectivity from Cationic to Anionic, Nature, (1992), pp. 500-505, vol. 359.
Gibbs, N. et al., Helix Bending in Alamethicin: Molecular Dynamics Simulations and Amide Hydrogen Exchange in Methanol, Biophysical Journal, (1997), pp. 2490-2495, vol. 72.
Gokel, G.W., Hydraphiles: Design, Synthesis and Analysis of a Family of Synthetic, Cation-Conducting Channels, Chem. Commun., (2000), pp. 1-9.
Gokel, G.W. et al., Synthetic Models of Cation-Conducting Channels, Chem. soc. Rev., (2001, pp 274-286, vol. 30.
Gokel, G.W. et al., Synthetic Organic Chemical Models for Transmembrane Channels, Acc. Chem. Res., (1996), pp. 425-432, vol. 29.
Hille, B., Pharmacological Modifications of the Sodium Channels of Frog Nerve, The Journal of General Physiology, (1968), pp. 199-219, vol. 51.
Hwang, T-C et al., C1 Channels in CF: Lack of Activation by Protein Kinase C and cAMP-Dependent Protein Kinase, Science, (1989), pp. 1351-1353, vol. 244.
Hyde, S.C. et al., Structural Model of ATP-Binding Proteins Associated with Cystic Fibrosis, Multidrug Resistance and Bacterial Transport, Nature, (1990), pp. 362-365, vol. 346.
Ido, Y. et al., Prevention of Vascular and Neural Dysfunction in Diabetic Rats by C-Peptide, Science, (1997), pp. 563-566, vol. 277.
Jullien, L. et al., The “CHUNDLE” Approach to Molecular Channels Synthesis of a Macrocycle-Based Molecular Bundle, Tetrahedron Letters, (1988), pp. 3803-3806, vol. 29:31.
Lear, J.D. et al., Synthetic Amphiphilic Peptide Models for Protein Ion Channels, Research Articles, (1988), 1177-1181, vol. 240.
Levitt, D.G., Kinetics of Movement in Narrow Channels, Current Topics in Membranes and Transport, (1984), pp. 181-197, vol. 21.
Li, M. et al., Cyclic AMP-Dependent Protein Kinase Opens Chloride Channels in Normal but no Cystic Fibrosis Airway Epithelium, Nature, (1988), pp. 358-360, vol. 331.
Merlin, D. et al., Cryptdin-3 Induces Novel Apical Conductance(s) in C1 Secretory, Including Cystic Fibrosis, Epithelia, Am J Physiol Cell Physiol, pp. C296-C302, vol. 280.
Miller, C., Ion Channels: Doing Hard Chemistry with Hard Ions, Current Opinion in Chemical Biology, (2000, pp. 148-151, vol. 4.
Montal, M., Design of Molecular Function: Channels of Communication, Annu. Rev. Biophys. Biomol. Struct., (1995), pp. 31-57, vol. 24.
Mutter, M. et al., Strategies for the De Novo Design of Proteins, Tetrahedron, (1988), pp. 771-785, vol. 44:3.
Oiki, S. et al., Channel Protein Engineering: Synthetic 22-mer Peptide from the Primary Structure of the Voltage-Sensitive Sodium Channel Forms Ionic Channels in Lipid Bilayers, Proc. Natl. Acad. Sci., (1988), pp. 2393-2397, vol. 85.
Reusch, R.N., Ion Recognition and Transport by Poly-(R)-3-Hydroxybutyrates and Inorganic Polyphosphates, Advances in Supramolecular Chemistry, pp. 49-98, vol. 7.
Rex, S. et al., Quantitative Studies on the Melittin-Induced Leakage Mechanism of Lipid Vesicles, Biochemistry, (1998), pp. 2336-2345, vol. 37.
Riordan, J.R. et al., Identification of the Cystic Fibrosis Gene: Cloning and Characterization of Complementary DNA, Science, (1989), pp. 1066-1073, vol. 245.
Rommens, J.M. et al., Identification of the Cystic Fibrosis Gene: Chromosome Walking and Jumping, Research Articles, (1989), pp. 1059-1065, vol. 245.
Saito, M. et al., BAX-Dependent Transport of Cytochrome C Reconstituted in Pure Liposomes, Nature Cell Biology, (2000), pp. 553-555, vol. 2.
Schlesinger, P.H. et al., Comparison of the Ion Channel Characteristics of Proapoptotic BAX and Antiapoptotic BCL-2, Proc. Natl. Acad. Sci., (1997), pp. 11357-11362, vol. 94.
Schlesinger, P.H., Measuring the pH of Pathogen-Containing Phagosomes, Methods in Cell Biology, pp. 289-311, vol. 45.
Starostin, A.V. et al., An Anion-Selective Analogue of the Channel-Forming Peptide Alamethicin, Biochemistry, (1999), pp. 6144-6150, vol. 38.
Steinmeyer, K. et al., Primary Structure and Functional Expression of a Developmentally Regulated Skeletal Muscle Chloride Channel, Nature, (1991), pp. 301-304, vol. 354.
Szoka, F., Jr. et al., Procedure for Preparation of Liposomes with Large Internal Aqueous Space and High Capture by Reverse-Phase Evaporation, Proc. Natl. Acad. Sci., (1978), pp. 4194-4198, vol. 75:9.
Tieleman, D.P. et al., Alamethicin Helices in a Bilayer and in Solution: Molecular Dynamics Simulations, Biophysical Journal, (1999), pp. 40-49, vol. 76.
Voyer, N. et al., A Novel Functional Artificial Ion Channel, J. Am. Chem. Soc., (1995), pp. 6599-6600, vol. 117.
Voyer, N. et al., Electrical Activity of Artificial Ion Channels Incorporated into Planar Lipid Bilayers, J. Chem. Soc., Perkin Trans, (1997), pp. 1469-1471, vol. 2.
Wagner, H. et al., Oligo-THF Peptides: Synthesis, Membrane Insertion, and Studies of Ion Channel Activity, Angew. Chem. Int. Ed. Engl., (1996), pp. 2643-2646, vol. 35:22.
Welsh, M.J., An Apical-Membrane Chloride Channel in Human Tracheal Epithelium, Science, pp. 1648-1650, vol. 232.
Welsh, M.J. et al., Chloride and Potassium Channels in Cystic Fibrosis Airway Epithelia, Nature, (1986), pp. 467-470, vol. 322.
Yang, L. et al., Barrel-Stave Model or Toroidal Model? A Case Study on Melittin Pores, Biophysical Journal, (2001), pp. 1475-1485, vol. 81.
Schlesinger et al. “A Hydrocarbon Anchored Peptide that Forms a Chloride-Selective Channel in Liposomes” Chem. Commun., vol. 8 (2002) pp. 840-841.
Yang et al. “Cyclic Hexapeptide of D,L-α-Aminoxy Acids as a S

Affiliated with

Also associated with

Rating

Synthetic ion channels does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Synthetic ion channels, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Synthetic ion channels will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3688091