Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acid esters
Patent
1986-02-21
1987-05-05
Evans, J. E.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carboxylic acid esters
26050117, 560 53, 560 59, 560126, 562500, C07C 6129, C07C 69757, C07C 9102
Patent
active
046634746
ABSTRACT:
Racemic endo- and exo-1-methoxybicyclo[2.2.2]oct-5-ene-2-carboxylic acids are starting materials for a novel and efficient synthesis of chiral 3R-[2-hydroxy-4-(1,1-dimethylheptyl)phenyl]-4R-(3-hydroxypropyl)-1R-cycloh exanol, a compound having valuable central nervous system (CNS) activity, particularly as an analgesic and as an antiemetic.
REFERENCES:
patent: 1861543 (1932-06-01), Moore et al.
patent: 2454351 (1948-11-01), Sows et al.
patent: 2460239 (1949-01-01), Pickel et al.
patent: 2460240 (1949-01-01), Pickel et al.
patent: 3071597 (1963-01-01), Kauer
patent: 3081334 (1963-03-01), Kauer
patent: 3526657 (1970-09-01), Loeffler
patent: 3636072 (1972-01-01), Cross et al.
patent: 3641128 (1972-02-01), Loeffler
patent: 3914322 (1975-10-01), Chappell et al.
patent: 4189431 (1980-02-01), Johnson et al.
patent: 4257976 (1981-03-01), Pavin et al.
patent: 4371720 (1983-02-01), Johnson et al.
Birch et al., J. Chem. Soc. (C), pp. 125-126 (1967).
Otani, Chem. Pharm. Bull., 21, pp. 2125-2129 (1973).
Yamada, Tetrahedron Lett., pp. 4237-4240 (1969).
Blackwood Robert K.
Evans J. E.
Frost Albert E.
Knuth Charles J.
Pfizer Inc.
LandOfFree
Synthetic intermediates for a chiral 3-(substituted-phenyl)-4-(3 does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Synthetic intermediates for a chiral 3-(substituted-phenyl)-4-(3, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Synthetic intermediates for a chiral 3-(substituted-phenyl)-4-(3 will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2400301