Synthetic immunoregulators and methods of use and preparation

Details Synthetic immunoregulators and methods of use and preparation Synthetic immunoregulators and methods of use and preparation

1982-12-20

1986-05-20

Nucker, Christine M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

424 89, 536 11, 536112, A61K 31715, A61K 3912, C07H 100, C08B 3702

Patent

active

045901813

ABSTRACT:
To regulate the immune response to an antigen, a subject is injected with the antigen and a polyanionic polysaccharide derivative having a molecular weight of between 10,000 and 600,000 selected to correspond to the antigen. For virus, as an example, mycodextran sulfate or pustulan sulfate may be used in sufficient quantities to stimulate cell-mediated immune responses without stimulating synthesis of gamma E globulin and gamma G globulin. The polyanionic polysaccharide may be injected along to stimulate cell-mediated immune responses to antigens in a diseased subject.

REFERENCES:
patent: 4359458 (1982-11-01), Nair et al.
patent: 4372883 (1983-02-01), Matuhashi et al.
McCarthy et al. Immunology, 32:963, 1977.

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