Synthetic, immunologically active peptides useful for the prepar

Details Synthetic, immunologically active peptides useful for the prepar Synthetic, immunologically active peptides useful for the prepar

1989-05-30

1992-05-26

Nucker, Christine

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

530350, C07K 300, A61K 3702

Patent

active

051169460

ABSTRACT:
Synthetic peptides constituted by at least two repeating, consecutive units of asparaginyl-proline (Asn-Pro).sub.n sequence, are described.
The peptides are powerful immunogens, capable of inducing in laboratory animals the formation of a high concentration of antibodies capable of reacting both with the (Asn-Pro).sub.n peptides, and with the immunodominant epitope of the circumsporozoite protein of Plasmodium falciparum.
The peptides, which can be obtained in a pure form by chemical synthesis, are particularly useful for preparing antimalarial vaccines and diagnostic kits for the determination of malaria in man.

REFERENCES:
Gibson et al., Predicted Conformations for the Immunodominant Region of the CP of the Human Malaria Parasite Plasmodium falciparum PNAS 86:5649-5653, 1986.
Dayhoff et al., A Model of Evolutionary Change in Proteins Atlas of Proteins Sequence & Structure 1972, vol. 5, 89-99.

Affiliated with

Also associated with

Rating

Synthetic, immunologically active peptides useful for the prepar does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Synthetic, immunologically active peptides useful for the prepar, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Synthetic, immunologically active peptides useful for the prepar will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-421017