Synthetic hepatitis B virus vaccine including both T cell and B

Drug – bio-affecting and body treating compositions – Lymphokine

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424 88, 514 13, 514 14, 514 15, 514 16, 530806, 530324, 530326, 530327, 530328, A61K 3929, C07K 706, C07K 708, C07K 710

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active

045992304

ABSTRACT:
Chemically synthesized polypeptides include amino acid residue sequences that substantially correspond to the amino acid residue sequences of T cell and B cell determinant portions of a natural, pathogen-related protein, in particular, a hepatitis B virus surface antigen (HBsAg). When administered to a host alone, as polymers or as carrier-bound conjugates, the polypeptides induce the proliferation of thymus-derived cells in hosts primed against hepatitis B virus.

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The Journal of Invest., 83, 112s-115s (1984).

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