Synthetic helizyme enzymes

Details Synthetic helizyme enzymes Synthetic helizyme enzymes

1990-01-16

1994-04-19

Wax, Robert A.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Peptides with at least one nonpeptide bond other than a...

530324, 530300, 530350, 435213, 435219, 435197, C07K 702, C07K 700, C12N 976, C12N 918

Patent

active

053046315

ABSTRACT:
The design, and synthesis of peptide-based molecules termed helizymes which possess catalytic activity are described herein The catalytic molecules of the invention comprise a number of amphiphilic helical peptides, which interact via hydrophobic interactions and which are bonded at their carboxyl ends to a multifunctional base. Active site residues functional for catalysis are positioned within or at the N-termini of the helical peptides. The helizyme molecule adopts a conformation in aqueous medium such that a substrate binding pocket is formed and such that functional active site geometry results from the association of the helical peptides Specifically exemplified helizymes possess specificities and at least one catalytic activity of chymotrypsin, trypsin and acetylcholine esterase.

REFERENCES:
Craik et al. "The Catalytic Role of the Active Site . . . " Science vol. 237 p. 909 Aug. 21, 1987.
Regan et al. (1988) Science 241:976-978.
Mutter (1988) TIBS 13:260-265.
Mutter and Tuchscherer (1988) Makromol. Chem. Rapid Commun. 9:437-443.
Mutter et al. (1988) Tetrahedron 44:771-785.
Mutter et al. (1988) Helvetica Chimica Acta 71:835-846.
Mutter et al. (1989) Proteins: Structure, Function, and Genetics 5:13-21.
Mutter and Vuilleumier (1989) Angew. Chemie (Intl ed.) 28:535-679.
DeGrado et al. (1989) Science 243:622-628.
Sasaki and Kaiser (1989) J. Am. Chem. Soc. 111:380-383.
Mutter (1985) Angew. Chem. Int. Ed. Engl. 24:639-653.
Vorherr et al. (1986) Helv. Chim. Acta 69:410-414.

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