Synthetic heat-stable enterotoxin polypeptide of Escherichia col

Details Synthetic heat-stable enterotoxin polypeptide of Escherichia col Synthetic heat-stable enterotoxin polypeptide of Escherichia col

1983-01-03

1985-10-08

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07C10352

Patent

active

045459312

ABSTRACT:
A synthetic polypeptide having at least about 40% of the antigenicity of biologic heat stable enterotoxin of E. coli. The synthetic polypeptide includes at least 14 amino acids in the sequence, from amino-terminus to carboxy-terminus, represented by the formula: CysCysGluLeuCysCysTyr(Asn)ProAlaCysAla(Thr)GlyCysAsn(Tyr) wherein the amino acid in parentheses may replace the immediately preceding amino acid residue, and at least one intramolecular disulfide bond formed between the Cys residues. The Cys residues that are not part of the intramolecular disulfide bond can be replaced by other amino acid residues or be bonded to substituent moieties.

REFERENCES:
Infect. Immun. 37, 550-557, (1982).
Proc. Nat'l. Acad. Sci. 77, 4011-4015, (1980).
J. Biol. Chem., vol. 256, (1981), 7744-7746.

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