Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Glycoprotein – e.g. – mucins – proteoglycans – etc.
Reexamination Certificate
2007-05-29
2007-05-29
Kam, Chih-Min (Department: 1656)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Glycoprotein, e.g., mucins, proteoglycans, etc.
C530S324000, C530S325000, C530S326000, C530S327000, C530S322000, C530S333000, C530S344000, C530S402000, C530S412000, C514S008100, C514S023000, C514S025000, C514S042000
Reexamination Certificate
active
11121731
ABSTRACT:
A new class of synthetic glycosulfopeptides (GSPs) which have one or more sulfated tyrosine residues and a glycan linked to the peptide, the glycan preferably including a sialyl Lewisxgroup or a sialyl Lewisagroup. In a preferred version the GSPs have an O-glycan comprising a β1,6 linkage to a GalNAc. The present invention further contemplates in vitro methods of the synthesis of these GSPs without the use of the cells and methods of their use in vivo as powerful anti-inflammatory antithrombotic, or anti-metastatic compounds. The invention also contemplates a method of synthesizing oligosaccharides by cleaving the glycan from the GSP.
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Cummings Richard D.
McEver Rodger P.
Dunlap Codding & Rogers P.C.
Kam Chih-Min
The Board of Regents of the University of Oklahoma
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