Synthetic glycolipides, a process for the preparation thereof an

Details Synthetic glycolipides, a process for the preparation thereof an Synthetic glycolipides, a process for the preparation thereof an

1985-02-05

1988-06-14

Griffin, Ronald W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 5, 424450, 424461, A61K 908, A61K 3166, A61K 3170

Patent

active

047512199

ABSTRACT:
Synthetic glycolipides having the general formula lipidyl-O-R wherein the lipidyl moiety is selected from the group consisting of 5-cholestene-3.beta.-yl, ceramidyl, phosphatidylethanolamine and diacylglycerol and R represents a group having the formula ##STR1## in which two symbols Z represent a glycopyranosyl rest and the other symbol Z a hydrogen atom or all three symbols Z represent a glycopyranosyl rest. These new glycolipides can be used for the solubilization of cholesterol in water or aqueous media, for the manufacture of lipide-vesicles or lipoproteins in which such a glycolipide is encapsulated as well as for the reduction of the cholesterol level in the blood plasma of mammals. Preferably the compound N-tris(.beta.-D-galactopyranosyloxymethyl)methyl-N.alpha.-(4-(5 cholesten-3.beta.-yloxy)succinyl)glycinamide is used.

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