Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1997-05-21
1999-03-30
Spector, Lorraine
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
530350, 536 235, 4353201, 435325, 4352523, 43525411, 435 691, C12N 1510, C12N 510, C07K 14705
Patent
active
058891676
ABSTRACT:
A synthetic human glucagon (hGlu) binding protein designated hGlu.DELTA.252-259 binding protein is cloned, expressed and used in an in vitro assay to screen for compounds that bind to the synthetic binding protein, including compounds that specifically stimulate or inhibit the binding of glucagon to the synthetic receptor. The invention includes the assay, the synthetic binding protein used in the assay, DNA encoding the synthetic binding protein, cells expressing the synthetic binding protein, and compounds identified through the use of the synthetic binding protein.
REFERENCES:
Chicchi, et al., "Alterations in receptor activation and divalent cation activation of agonist binding . . . ", J. Biol. Chem., 21 Mar. 1997, vol. 272, No. 12 pp. 7765-7769.
Carruthers,et al., "Synthesis and expression of a gene for the rat glucgon receptor . . . ", J. Biol. Chem., 18 Nov. 1994, vol. 269, No. 46, pp. 29321-29328.
MacNiel, et al., "Cloning and expression of a human glucagon receptor.", Biochem. Biophys. Res. Comm., 14 Jan. 1994, vol. 198, No. 1, pp. 328-334.
Unson,et al., "Characterization of deletion and truncation mutants of the rat glucagon receptor.", J. Biol. Chem., 17 Nov. 1995, vol. 270, No. 46, pp. 27720-27727. glucagon receptor expressed . . .", j. Biol. Chem., 3 Nov. 1995, vol. 270, No. 44, pp. 26466-26472.
Hamilton, et al., nursing 86 Drug Handbook, Pennsylvania, USA Springhouse Corporation 1986, pp. 494, col. 2 and p. 495, col. 1.
Cascieri Margaret A.
Chicchi Gary A.
Graziano Michael P.
Hey Patricia J.
Kaufman Claire M.
Merck & Co. , Inc.
Spector Lorraine
Tribble Jack L.
Yablonsky Michael D.
LandOfFree
Synthetic glucagon binding proteins does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Synthetic glucagon binding proteins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Synthetic glucagon binding proteins will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1216349