Synthetic GHRH analogs

Details Synthetic GHRH analogs Synthetic GHRH analogs

1987-02-05

1990-04-03

Phillips, Delbert R.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

C07K 710

Patent

active

049141899

ABSTRACT:
Human pancreatic GRF (hpGRF), rat hypothalamic GRF (rGRF) and porcine hypothalamic GRF (pGRF) have been earlier characterized and synthesized. The invention provides synthetic peptides which are extremely potent in stimulating the release of pituitary GH in animals, including humans, which have resistance to enzymatic degradation in the body, and which have the sequence: ##STR1## wherein Q.sup.1 is an omega or alpha-omega substituted alkyl,

REFERENCES:
patent: 4528190 (1985-07-01), Vale, Jr. et al.
patent: 4622312 (1986-11-01), Felix et al.
patent: 4659693 (1987-04-01), Nestor
Chem. Abs., vol. 97, 1982, 195098W.
Chem. Abs., vol. 107, 1987, 131274t.
Coy et al., Peptides 7, 49-52, (1986).
Kovacs, et al., Life Science, 42, 27-35, (1988).
Sato et al., Biochem. Biophys. Research Communication, 149, 531-537, (1987).
Chemical Abstracts, vol. 102, 1985, 149761f.

Affiliated with

Also associated with

Rating

Synthetic GHRH analogs does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Synthetic GHRH analogs, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Synthetic GHRH analogs will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1358255