Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2006-07-18
2006-07-18
Smith, Lynette R. F. (Department: 1645)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C435S069300, C435S069700, C536S023500, C536S023700, C424S268100, C424S272100, C530S350000
Reexamination Certificate
active
07078507
ABSTRACT:
Synthetic gene sequences encoding erythrocyte binding protein of a malaria pathogen for the expression of the erythrocyte binding protein. The codon composition of the synthetic gene sequences approximates the mammalian codon composition. The synthetic gene sequences are useful for incorporation into the DNA vaccine vectors, for the incorporation into various expression vectors for production of malaria proteins, or both. The synthetic genes may be modified to avoid post-translational modification of the encoded protein in hosts. Administration of the synthetic gene sequences, or the encoded protein, as an immunization agent is useful for induction of immunity against malaria, treatment of malaria, or both.
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Rudinger et al, in “Peptide Hormones”, edited by Parsons, J.A., University Park Press, Jun. 1976.
Biochemical and Biophysical Research Communications 1999, 261; 445-451.
GeneEmbl, Accession No. PFU27384 or PFU 78724.
Kim et al 1997, Molecular and Biochemical Parasitology 1997, 84: 241-24.
Narum et al., “Codon Optimization of Gene Fragments EncodingPlasmodium falciparumMerzoite Proteins Enhances DNA VAccine Protein Expression and Immunogenicity in Mice,”Infection and Immunity(2001) , vol. 69, No. 12, pp. 7250-7253.
Liang and Sim, 1997, “Conservation of structure and function of the erythrocyte-binding domain ofPlasmodium falciparumEBA-175,”Mol Biochem Parasitol84: 241.
Fuhrmann Steve
Liang Hong
Narum David
Sim B. Kim Lee
Baskar Padma
Knobbe Martens Olson & Bear LLP
Smith Lynette R. F.
The United States of America as represented by the Secretary, De
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