Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Reexamination Certificate
2003-07-28
2010-02-02
Nickol, Gary B (Department: 1646)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
C435S069500, C536S023100, C530S350000
Reexamination Certificate
active
07655437
ABSTRACT:
The invention relates to the synthetic gene coding for hG-CSF which enables expression inE. coliwith an improved expression level of the recombinant hG-CSF regarding the total cellular proteins after expression.
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Krishna Rao et al., Mol. Biotechnol., 2008, 38(3):221-32.
Devlin et al., Alteration of amino-terminal codons of human granulocyte-colony-stimulating factor increases expression levels and allows efficient processing by methionine aminopeptidase inEscherichia coli, Gene, 1988, p. 13-22, vol. 65, Elsevier Science Publishers B.V., USA.
Kane, Effects of rare codon clusters on high-level expression of heterologous proteins inEscherichia coli, Current Opinion in Biotechnology, 1995, p. 494-500, vol. 6, Current Biology Ltd., USA.
Jeong et al., Secretory Production of Human Granulocyte Colony-Stimulating Factor inEscherichia coli, Protein Expression and Purification, 2001, p. 311-318, vol. 23, Academic Press, USA.
Makrides, Strategies for achieving high-level expression of genes inEscherichia coli, Microbiological Reviews, Sep. 1996, p. 512-538, American Society for Microbiology, USA.
Jevsevar Simona
Menart Viktor
Lek Pharmaceuticals d.d.
Luedeka Neely & Graham P.C.
Nickol Gary B
Xie Xiaozhen
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