Synthetic gagpol genes and their uses

Details Synthetic gagpol genes and their uses Synthetic gagpol genes and their uses

2008-05-27

2008-05-27

Parkin, Jeffrey S. (Department: 1648)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C424S188100, C424S208100

Reexamination Certificate

active

10276482

ABSTRACT:
The present invention relates to synthetic gag and gagpol genes optimized for high level expression via codon optimization and the uses thereof for the efficient generation of vector particles. The invention further relates to the generation of packaging cells and vaccines based on the synthetic gag and gagpol genes.

REFERENCES:
patent: WO 98/34640 (1998-08-01), None
patent: WO 00/15819 (2000-03-01), None
patent: WO 00/39304 (2000-07-01), None
Ellington, A., and J. M. Cherry, 1997, Characteristics of Amino Acids, Curr. Prot. Molec. Biol. A.1C.1-A.1C.12.
2006 Instructions to Authors, 2006, J. Virol. 80(1):15-16, (1-17).
Murphy, F. A., 1996, Virus Taxonomy, in Fields Virology, Third Edition, Fields, B. N., et al., eds., Lippincott-Raven Publishers, Philadelphia, pp. 40-41.
Xiang, G., et al., 2003, Translational recoding signals between gag and pol in diverse LTR retrotransposons, RNA 9(12):1422-1430, abstract provided.
Graf et al., “Concerted action of multiple cis-acting sequences is required for rev dependence of late human immunodeficiency type 1 gene expression,”J. Virol., 74:10822-10826, 2000.
Haas et al., “Codon usage limitation in the expression of HIV-1 envelope glycoprotein,”Curr. Biol., 6:315-324, 1996.
Kotsopoulou et al., “A rev-independent human immunodeficiency virus type 1 (HIV-1)-based vector that exploits a codon-optimized HIV-1 gag-pol gene,”J. Virol., 74:4839-4852, 2000.
Luban and Goff, “Mutational analysis of cis-acting packaging signals in human immunodeficiency virus type 1 RNA,”J. Virol., 68:3784-3793, 1994.
Qiu et al., “Evaluation of novel human immunodeficiency virus type 1 gag DNA vaccines for protein expression in mammalian cells and induction of immune responses,”J. Virol., 73:9145-9152, 1999.
Schneider et al., “Inactivation of the human immunodeficiency virus type inhibitory elements allows rev-independent expression of gag and gag/protease and particle formation,”J. Virol., 71:4892-4903, 1997.
Schwartz et al., “Mutational inactivation of an inhibitory sequence in human immunodeficiency virus type 1 results in rev-independent gag expression,”J. Virol., 66:7176-7182, 1992.

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