Synthetic drug molecules that mimic metalloenzymes

Details Synthetic drug molecules that mimic metalloenzymes Synthetic drug molecules that mimic metalloenzymes

1992-01-17

1993-06-08

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

540145, A61K 31555, C07D48722

Patent

active

052179664

ABSTRACT:
Synthetic enzymes that mimic the catalytic activity of naturally occurring enzymes by providing catalytic sites enclosed in cages that protect the sites from undesirable molecules and attract and permit entry of the relevant substrates are disclosed. Molecules that mimics the catalytic activity of superoxide dismutase and catalase, pharmaceutical compositions containing these molecules, and methods for using these compositions are also disclosed.

REFERENCES:
patent: 4029819 (1977-06-01), Michelson
patent: 4129644 (1978-12-01), Kalopissis et al.
patent: 4695456 (1987-09-01), Wilder
Heterocycles, 16, 417, 1981.
J. Am. Chem. Soc. 111, 2105, 1989.
J. Am. Chem. Soc. 110, 4242, 1988.
J. Am. Chem. Soc. 104, 340, 1982.

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