Synthetic derivatives of paraherquamide

Details Synthetic derivatives of paraherquamide Synthetic derivatives of paraherquamide

1988-08-12

1990-12-18

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Silicon containing doai

514 81, 514250, 544229, 544230, C07D49122, A61K 31495

Patent

active

049786563

ABSTRACT:
There are disclosed synthetic derivatives of the natural product paraherquamide. The synthetic derivatives are prepared by reactions at the parahequamide A, B, E, F and G rings, that is at carbon atoms 14 to 16, the lactam ring and carbon atoms 24 to 26 as well as carbon atoms 5 and 12. The compounds are active antiparasitic agents and compositions for that use are also disclosed.

REFERENCES:
patent: 4873247 (1989-10-01), Goegelman et al.
patent: 4923867 (1990-05-01), Blizzard et al.
Yamazaki et al., Chemical Abstracts, vol. 95, No. 19321 (1981).
Yamazaki et al. Tetrahedron Letter 22 pg. 135-136 (1981).

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