Synthetic decapeptide having the activity of the luteinizing hor

Details Synthetic decapeptide having the activity of the luteinizing hor Synthetic decapeptide having the activity of the luteinizing hor

1974-01-14

1976-04-27

Gotts, Lewis

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424177, C07C10352, C07G 700

Patent

active

039534162

ABSTRACT:
A synthetic decapeptide, L-pglutamyl-L-histidyl-L-tryptophanyl-L-seryl-L-tyrosyl-glycyl-L-leucyl-L- arginyl-L-prolyl-glycinamide which has the hormonal activities of the luteinizing hormone releasing hormone (LRH) of the hypothalamus gland of mammals is produced by utilizing as the key starting materials, the amino acids, glutamic acid or pyroglutamic acid, histidine, tryptophan, serine, tyrosine, glycine, leucine, arginine, and proline. Synthesis of the decapeptide is accomplished by coupling, in appropriate combinations of appropriate protected forms of the amino acids, and finally deprotecting to yield the amide, L-pglutamyl-L-histidyl-L-tryptophanyl-L-seryl-L-tyrosyl-glycyl-L-leucyl-L- arginyl-L-prolyl-glycinamide.

REFERENCES:
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Chem. Eng. News, 49, 7 (1971).
Matsuo et al., Biochem. Biophys. Res. Comm., 43, 1334-1339 (1971).

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