Synthetic compounds to inhibit intestinal absorption of choleste

Details Synthetic compounds to inhibit intestinal absorption of choleste Synthetic compounds to inhibit intestinal absorption of choleste

1982-05-17

1986-07-22

Roberts, Elbert L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 5, 26023955A, 2603972, 514172, 514169, A01N 3100, A61K 31705, A61K 3158, A61K 3156

Patent

active

046020039

ABSTRACT:
Synthetic sapogenin and sterol compounds, administered orally to warm-blooded animals, inhibit the absorption of cholesterol and are useful in the treatment of hypercholesterolemia. Particular compounds suitable for such purposes include glycosides with spirostane, spirostene, or cholesterol aglycones, and esters of spirostanes, spirostenes and cholesterol.

REFERENCES:
patent: 3160626 (1964-12-01), Oxley
patent: 3303187 (1967-02-01), Rubin
patent: 3992315 (1976-11-01), Dibb et al.
patent: 4188379 (1980-02-01), Pegel
patent: 4198401 (1980-04-01), Pegel
patent: 4242502 (1980-12-01), Malinow et al.
patent: 4254111 (1981-03-01), Pegel et al.
patent: 4260603 (1981-04-01), Pegel et al.
patent: 4265886 (1981-05-01), Pegel
Kintya et al., "Search for Hypochotesferemic Agents Among a Group of Steroid Glycosides", Kim. Farm. Zh (1981) 15:9, pp. 56-60.
M. R. Malinow, et al., "Prevention of Hypercholesterolemia in Monkeys (Macaca fascicularis) by Digitonin", Am. J. Clin. Nut. 31:814-818 (1978).
R. J. Morris, et al., "Isolation, Purification, and Structural Identity of an Alfalfa Root Saponin", J. Org. Chem., 26:1241-1243 (1961).
Anderson, "Effect of Alfalfa Saponin on the Performance of Chicks and Laying Hens", Chem. Abs. 52:2194f (1958).
Bite et al., "Synthesis of Steroid Glycosides", Chem. Abs. 66:38204v (1967).
Cayen et al., "Effect of Diosgenin on Lipid Metabolism in Rats", J. Lipid Research 20:162-173 (1979).
Griminger et al., "Dietary Saponin and Plasma Cholesterol in the Chicken", Proc. Soc. Exp. Biol. Med., 99:424-426 (1958).
Ishaaya et al., "Soybean Saponins, IX., Studies of Their Effect on Birds, Mammals and Cold-Blooded Organisms", J. Sci. Fd. Agric. 20:433-436 (1969).
Malinow et al., "Effect of Alfalfa Saponins on Intestinal Cholesterol Absorption in Rats", Am. J. Clin. Nutr. 30:2061-2067 (1977).
Malinow et al., "Cholesterol and Bile Acid Balance in Macaca fascicularis", J. Clin. Invest. 67:156-162 (1981).
Morgan et al., "The Interactions Between Dietary Saponin, Cholesterol and Related Sterols in the Chick", Poultry Sci. 51:677-682 (1972).
Newman et al., "Dietary Saponin, A Factor Which May Reduce Liver and Serum Cholesterol Levels", Poultry Sci. 37:42-46 (1958).
Oakenfull, "Effects of Saponins on Bile Acids and Plasma Lipids in the Rat", Br. J. Nutr. 42:209-216 (1979).
Reshef et al., "Effect of Alfalfa Saponins on the Growth and Some Aspects of Lipid Metabolism of Mice and Quails", J. Sci. Fd. Agric. 27:63-72 (1976).
Segal et al., "Hemolytic Properties of Synthetic Glycosides", Biol. Abs. 67:57966 (1979).
Sofowora et al., "Synthesis of 3-.beta.-Glycosides of Diosgenin, Yamogenin and Gitogenin", Biol. Abs. 63:4467 (1977).
Topping et al., "Effects of Dietary Saponins on Fecal Bile Acids and Neutral Sterols, Plasma Lipids, and Lipoprotein Turnover in the Pig", Am. J. Clin. Nutr. 33:783-786 (1980).
Topping et al., "Prevention of Dietary Hypercholesterolemia in the Rat by Soy Flour High and Low in Saponins", Nutr. R. Intl. 22:513-519 (1980).
Wilcox et al., "Serum and Liver Cholesterol, Total Lipids and Lipid Phosphorus Levels of Rats Under Various Dietary Regimens", Am. J. Clin. Nutr. 9:236-243 (1961).
Merck Index (1976), pp. 439 and 1217.
"Steroids" by Fieser et al (1959), p. 28.

Affiliated with

Also associated with

Rating

Synthetic compounds to inhibit intestinal absorption of choleste does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Synthetic compounds to inhibit intestinal absorption of choleste, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Synthetic compounds to inhibit intestinal absorption of choleste will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-866136