Synthetic chollera vaccine

Details Synthetic chollera vaccine Synthetic chollera vaccine

1984-08-23

1988-06-14

Kight, John

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

424 88, 514837, 530326, A61K 3902

Patent

active

047510641

ABSTRACT:
A synthetic vaccine against cholera and against heat-labile toxin of E. coli comprising a conjugate of a high-molecular weight carrier with a synthetic polypeptide corresponding to part of the sequence of Subunit B of natural cholera toxin. The sequences of choice are those corresponding to sequences 45 to 64, 50 to 64 and 8 to 20 of Subunit B, or slightly modified sequences, similar to the above.

REFERENCES:
patent: 4125492 (1978-11-01), Cautricasas et al.
patent: 4411888 (1983-10-01), Rlipstein et al.
patent: 4479940 (1984-10-01), Bizzini
Delbendi et al., Approach to a Synthetic Vaccine Against Cholera, C.A. No. 70627n (vol. 101) 1984.
Lai, Determination of the Primary Structure of Cholera Toxin B Subunit; JBC 252(20) 1977, pp. 7249-7256.
Mekalanso et al., Cholera Toxin Gene, C.A. No. 62626a, vol. 100, 1983.
Klipstein et al., Properties of Synthetically Produced E coli LT Infertion Immunity 39(1) 1983, pp. 117-121.
Hopp et al. "Prediction of Protein Antigenic Determiment of Amino Acid Sequence" PNAS 78(6) 1981, pp. 3824-3828.
Yamamoto et al., Primary Structure of Heat-Coiled: Enterotoxin Produced by E coli . . . Human" JBC 259(80) 1984, p. 5037.
Klipstein et al., Immunity & Inf. 39(1) 1983, p. 117.
CA. #134405k, vol. 94, 1981, Amino Acid Sequence Homolopy between Cholera Toxin and . . . Toxin.
Wolf, Marc et al., "Structure-Function Studies of Cholera Toxin and Its A and B", The Journal of Biological Chemistry, vol. 256, No. 11 (1981).
Duffy, Lawrence, et al., "Involvement of Arginine Residues in the Binding Site of Cholera Toxin Subunit B", Biochemical and Biophysical Research Communications, Dept. of Physiological Chem. and Pharm, Roche Institute of Molecular Biology, Nutley, N.J. 07110, vol. 91, No. 3, (1979).
Arnon, Ruth, et al., "Studies on the Chemical Basis of the Antigenicity of Proteins", J. Biochem., Department of Biophysics, The Weizmann Institute of Science, Rehovoth, Israel (1960).

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