Synthetic catalytic free radical scavengers useful as antioxidan

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heavy metal containing doai

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556 45, A61K 3128, C07F 1300

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active

058278800

ABSTRACT:
The invention provides antioxidant salen-metal complexes, compositions of such antioxidant salen-metal complexes having superoxide activity, catalase activity, and/or peroxidase activity, compositions of salen-metal complexes in a form suitable for pharmaceutical administration to treat or prevent a disease associated with cell or tissue damage produced by free radicals such as superoxide, and cosmetic and free radical quenching formulations of salen metal compounds.

REFERENCES:
patent: 5106841 (1992-04-01), Scheer
patent: 5223538 (1993-06-01), Fridovich et al.
patent: 5403834 (1995-04-01), Malfroy-Camine et al.
Boucher, J. Inorg. Nucl. Chem., vol. 36, pp. 531-536 (1974).
Matsushita, et al., "Reactions of Manganese(III) Schiff Base Complexes with Superoxide Ion in Dimethyl Sulfoxide," Bull. Chem. Soc. Jpn., 54:3743-3748.
Coleman et al., "Characterization and Electrochemistry of Manganese (III) complexes Containing Pentadentate Ligands," Inorg. Chem., 20:1253-1258 (1981).
Czapski and Goldstein, "Superoxide Scavengers and Sod or Sod Mimics," Antioxidant in Therapy and Preventive Medicine, Eds. Emerit et al., Plenum Press, New York, pp. 45-50 (1990).
de Garavilla et al., "Novel Low-Molecular-Weight Superoxide Dismutase Mimic Deferoxamine-Manganese Improves Survival Following Hemorrhagic and Endotoxic Shock," Drug Development Research, 25:139-148 (1992).
Foye, "Radio Protective Drugs," Burger's Medicinal Chemistry 4th Ed., Wolf ed. pp. 11, 22, 29-35, 39, 44 (1981).
Fu et al., "Mechanistic Study of Synthetically Useful Model Using the Hypersensitive Prove trans-2-Phenyl-1-vinylcyclopropane," J. Org. Chem., 56:6497-6500 (1991).
Jacobsen, National Science Foundation, Presidential Young Investigator Award, Grant Number CHE-9057740 (1990).
Jacobsen et al., "Electronic Tuning of Asymmetric Catalysts," J. Org. Chem., 113:6703-6704 (1991).
Jacobsen et al., "Highly Enantioselective Epoxidation Catalysts Derived from 1,2-Diaminocyclohexane," J. Am. Chem. Soc., 113:7063-7064 (1991).
Jacobsen, "Chiral Complexes Designed to Catalyze Organic Reactions," National Institute of General Medical Sciences Notice of Grant Award, Grant Number: 1 R01 GM 43214-01A1 (1991).
Kensler et al., "Inhibition of Tumor Promotion by a Biomimetic Superoxide Dismutase," Science, 75-77 (1983).
Kessel et al., "Iron (III), Manganese (III), and Cobalt (III) Complexes with Single Chelating o-Semiquinone Ligands," Inorg. Chem., 19:1170-1178 (1980).
Lee and Jacobsen, "Enantioselective Epoxidation of Conjugated Dienes and Enynes. Trans-Epoxides from Cis Olefins," Tetra. Letts., 32:6533-6536 (1991).
Lee et al., "Enantiomerically Pure Epoxychromans via Asymmetric Catalysis," Tetra. Letts., 32:5055-5058 (1991).
Matsushita et al., "The Preparation and Characterization of Dichloromanganese (IV) Schiff Base Complexes," Bull. Chem. Soc. Jpn., 54:2646-2651 (1981).
Nagano et al., "Superoxide Dismutase Mimics Based on Iron in vito," J. Biol. Chem., 264:9243-9249 (1989).
Pasini et al., "Optically active Complexes of Schiff Bases. Part 4. An Analysis of the Circular-dichroism Spectra of Some Complexes of Different Co-ordination Numbers with Quadridentate schiff Bases of Optically Active Diamines," J.C.S. Dalton, pp. 346-356 (1977).
Sittig, Handbook of Toxic and Hazardous Chemicals and Carcinogens, pp. 559-562, 639-641, 243-248 (1985).
Yamamoto et al., "Anti-tumor Promoting Action of Phthalic Acid Mono-n-butyl Ester Cupric Salt, A Biomimetic Superoxide Dismutase," Carcinogenesis, 11:749-754 (1990).
Zhang et al., "Enantioselective Epoxidation of Unfunctionalized Olefins Catalyzed by (Salen) manganese Complexes," J. Am. Chem. Soc., 112:2801-2803 (1990).
Zhang and Jacobsen, "Asymmetric Olefin Epoxidation with Sodium Hypochlorite Catalyzed by Easily Prepared Chiral Mn(III) Salen Complexes," J. Org. Chem., 56:2296-2298 (1991).
Baudry et al., Biochemical and Biophisical Research Communications, vol. 192, No. 2, pp. 964-968 (1993).
Aguiari et al., Inorganica Chimica Acta, vol. 219, pp. 135-146, (1994).

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