Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2005-05-31
2005-05-31
Henley, III, Raymond J. (Department: 1614)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C556S045000
Reexamination Certificate
active
06900198
ABSTRACT:
The invention provides antioxidant salen-metal complexes, compositions of such antioxidant salen-metal complexes having superoxide activity, catalase activity, and/or peroxidase activity, compositions of salen-metal complexes in a form suitable for pharmaceutical administration to treat or prevent a disease associated with cell or tissue damage produced by free radicals such as superoxide, and cosmetic and free radical quenching formulations of salen metal compounds.
REFERENCES:
patent: 5106841 (1992-04-01), Scheer
patent: 5223538 (1993-06-01), Fridovich et al.
patent: 5403834 (1995-04-01), Malfroy-Camine et al.
patent: 5696109 (1997-12-01), Malfroy-Camine et al.
patent: 6046188 (2000-04-01), Malfroy-Camine et al.
patent: WO 93/03838 (1993-03-01), None
Aguiari, et al.,Inorganica Chimica Acta,219:135-146 (1994).
Baudry, fet al.,Biochemical and Biophysical Research Communications,192(2):964-968 (1993).
Bruce, et al.,Abstr. Soc. Neurosci.,19:1680 (1993).
Boucher,J. Inorg. Nucl. Chem.,36:531-538 (1974).
Coleman, et al.,Inorg. Chem.,20:1253-1258 (1981).
Czapski, et al., “Superoxide Scavengers and Sod or Sod Mimics,” inAntioxidants in Therapy and Preventive Medicine,Eds. Emerit, et al., Plenum Press, New York, pp. 45-50, date not available.
de Garavilla, et al.,Drug Development Research,25:139-148 (1992).
Foye, “Radioprotective Drugs,” inBurger's Medicinal Chemistry,Fourth Edition, Part III, pp. 11, 22, 29-35, 39, 44 (1981).
Fu, et al.,J. Organic Chem.,113:6703-6704, date not available.
Ito, et al.,Chemical Abstracts,vol. 111, Abstract No. 153260 (1989).
Jacobsen, National Science Foundation, Presidential Young Investigator Award, Grant No. CHE-9057740 (1990).
Jacobsen, National Institute of General Medical Sciences Notice of Grant Award, Grant No. 1 R01 GM 43214- 01A1 (1991).
Jacobsen, et al.,J. Organic Chem.,113:6703-6704 (1991).
Jacobsen, et al.,J. Amer. Chem. Soc.,113:7063-7064 (1991).
Kensler, et al.,Science,221:75-77 (1983).
Kessel, et al.,Inorg. Chem.,19:1170-1178 (1980).
Lee, et al.,Tetrahedron Letters,32(38):5055-5058 (1991).
Lee, et al.,Tetrahedron Letters,32(45):6533-6536 (1991).
Matsushita, et al.,Chemical Abstracts,vol. 96, Abstract No. 114881 (1981).
Matsushita, et al.,Bull. Chem. Soc. Jpn.,54:2646-2651 (1981).
Matsushita, et al.,Bull. Chem. Soc. Jpn.,54:3743-3748 (1981).
Nagano, et al.,J. Biol. Chem.,264(16):9243-9249 (1989).
Pasini, et al., “Optically Active Complexes of Schiff Bases. Part 4. An Analysis of the Circular-dichroism Spectra of some Complexes of Different Co-ordination Numbers with Quadridentate Schiff Bases of Optically Active Diamines,” J.C.S. Dalton, pp. 346-356, date not available.
Sittig,Handbook of Toxic and Hazardous Chemicals and Carcinogens,pp. 559-562, 639-641, 243-248 (1985).
Yamamoto, et al.,Carcinogenesis,11(5):749-754 (1990).
Zhang, et al.,J. Am. Chem. Soc.,112:2801-2803, date not available.
Zhang, et al.,J. Am. Chem. Soc.,56:2296-2298, date not available.
Doctrow Susan Robin
Malfroy-Camine Bernard
Eukarion, Inc.
Henley III Raymond J.
Townsend & Townsend & Crew LLP
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