Synthetic calcitonin peptides

Details Synthetic calcitonin peptides Synthetic calcitonin peptides

1991-06-05

1994-11-15

Lee, Lester L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530307, 530324, A61K 3700, A61K 3702, A61K 3730, C07K 500

Patent

active

053648404

ABSTRACT:
Synthetic hypocalcemic peptides which are superior in biological properties to native calcitonins as clinically useful agents. The peptides comprise analogues of native calcitonins having amino acid additions at the N-terminal position which, either alone or together with substitutions, and deletions at other residues, act to improve potency, prolong duration of the hormonal effect, and increase oral or nasal bioavailability. Methods are provided for the synthesis of these peptides.

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