Synthetic calcitonin mimetics

Details Synthetic calcitonin mimetics Synthetic calcitonin mimetics

1995-04-04

1997-12-16

Tsang, Cecilla J.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

15 to 23 amino acid residues in defined sequence

530327, 530328, 514 13, 514 14, 514 15, A61K 3106, A61K 3810, C07K 706, C07K 700

Patent

active

056986726

ABSTRACT:
The invention provides synthetic calcitonin mimetics. The mimetics of the present invention may include modifications that further enhance desired characteristics, such as oral bioavailability, while maintaining or enhancing inhibition of bone resorption. Related pharmaceutical compositions and methods are also disclosed.

REFERENCES:
Ngo et al., in The Protein Folding Problem and the Tertiary Structure Prediction, 1994, Merz et al (Ed.), Birkhauser, Boston, MA, pp. 433 and 492-495.
Inoue A. et al. Structure/activity relationship of eel calcitonin. eur. J. Biochem., 201, 607-614, 1991.
D'Santos C.S. et al. Biologically active derivatizable salmon calcitonin analogs:design, synthesis, and application. Endocrinology, 123(3), 1483-1488, 1988.
Kaiser E.T. The design of peptides and proteins. Annals NY Acad. Sci. 471, 233-238, 1986.
Yates, et al., Endocrinology 126 (6): 2845-2849, 1990.
Orlowski et al., Eur. J. Biochem. 162: 399-402, 1987.
Rinehart et al., J. Am. Chem. Soc. 103: 6517-6520, 1981.
Moe et al., Biochemistry 24: 1971-1976, 1985.

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