Synthetic calcitonin-gene-related peptides for lowering blood pr

Details Synthetic calcitonin-gene-related peptides for lowering blood pr Synthetic calcitonin-gene-related peptides for lowering blood pr

1983-07-08

1985-07-23

Moyer, Donald B.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

2601225R, 424 95, A61K 3702, C07C10352

Patent

active

045308381

ABSTRACT:
CGRP (calcitonin-gene-related peptide) has the formula: ##STR1## A related peptide has the residue Lys instead of Glu in the 35-position. CGRP or this homolog or pharmaceutically acceptable salts thereof, dispersed in a pharmaceutically acceptable liquid or solid carrier, can be administered to mammals, including humans, to influence memory, mood and pain appreciation and to achieve a substantial lowering of blood pressure or gastric acid secretion over an extended period of time. They also may be administered to affect ingestion behavior, taste and sensory perception.

REFERENCES:
Amara et al., "Alternative RNA Processing . . . ", Nature, vol. 298, 15, Jul. 1982.

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